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首页> 外文期刊>Cytokine >Case-control study of rhinoconjunctivitis associated with IL5RA polymorphisms in Japanese women: The Kyushu Okinawa Maternal and Child Health Study
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Case-control study of rhinoconjunctivitis associated with IL5RA polymorphisms in Japanese women: The Kyushu Okinawa Maternal and Child Health Study

机译：日本女性鼻结膜炎与IL5RA基因多态性的病例对照研究：九州冲绳母婴健康研究

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Background: Epidemiological research on the relationship between single nucleotide polymorphisms (SNPs) in the IL5RA gene and allergic disorders is limited. We examined the relationship between IL5RA SNPs and risk of rhinoconjunctivitis in young adult Japanese women. Methods: Included were 393 women who met the criteria of the International Study of Asthma and Allergies in Childhood (ISAAC) for rhinoconjunctivitis. Controls were 767 women without rhinoconjunctivitis according to the ISAAC criteria who had not been diagnosed with allergic rhinitis by a doctor. Adjustment was made for age, region of residence, presence of older siblings, smoking, and education. Results: Compared with the CC genotype of SNP rs6771148, the CG genotype, but not the GG genotype, was significantly associated with a reduced risk of rhinoconjunctivitis: the adjusted OR for the CG genotype was 0.76 (95% CI: 0.58-0.99). No evident associations were found between SNPs rs17882210, rs3804797, rs334809, rs9831572, or rs17881144 and rhinoconjunctivitis. The ACTAGA haplotype of rs17882210, rs3804797, rs334809, rs9831572, rs6771148, and rs17881144 was significantly inversely associated with rhinoconjunctivitis (crude OR=0.58, 95% CI: 0.37-0.88) while the GTAGCA haplotype was significantly positively related to rhinoconjunctivitis (crude OR=1.74, 95% CI: 1.14-2.65). No significant interactions affecting rhinoconjunctivitis were observed between any of the six SNPs and smoking. Conclusion: This is the first study to show significant associations between IL5RA SNP rs6771148, the ACTAGA haplotype, and the GTAGCA haplotype and the risk of rhinoconjunctivitis. We did not find evidence for interactions affecting rhinoconjunctivitis between any of the IL5RA SNPs and smoking.
机译：背景：关于IL5RA基因中的单核苷酸多态性（SNP）与过敏性疾病之间关系的流行病学研究有限。我们检查了IL5RA SNPs与年轻成年日本女性鼻结膜炎风险之间的关系。方法：包括393名符合国际儿童哮喘和变态反应研究（ISAAC）鼻结膜炎标准的妇女。根据ISAAC标准，对照组为767名没有鼻结膜炎的女性，这些女性没有被医生诊断为过敏性鼻炎。调整了年龄，居住地区，年长的兄弟姐妹，吸烟和受教育程度。结果：与SNP rs6771148的CC基因型相比，CG基因型而非GG基因型与降低的鼻结膜炎风险显着相关：校正后的CG基因型OR为0.76（95％CI：0.58-0.99）。 SNP rs17882210，rs3804797，rs334809，rs9831572或rs17881144与鼻结膜炎之间未发现明显关联。 rs17882210，rs3804797，rs334809，rs9831572，rs6771148和rs17881144的ACTAGA单倍型与鼻结膜炎呈显着负相关（粗OR = 0.58,95％CI：0.37-0.88），而GTAGCA单倍型与鼻结膜炎呈正相关（ 1.74，95％CI：1.14-2.65）。六个SNP与吸烟之间均未观察到影响鼻结膜炎的显着相互作用。结论：这是第一个显示IL5RA SNP rs6771148，ACTAGA单倍型和GTAGCA单倍型与鼻结膜炎风险之间显着相关性的研究。我们没有发现任何IL5RA SNP与吸烟之间相互作用会影响鼻结膜炎的证据。

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