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首页> 外文期刊>Cytokine >Role of IL6, IL12B and VDR gene polymorphisms in Plasmodium vivax malaria severity, parasitemia and gametocytemia levels in an Amazonian Brazilian population
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Role of IL6, IL12B and VDR gene polymorphisms in Plasmodium vivax malaria severity, parasitemia and gametocytemia levels in an Amazonian Brazilian population

机译：IL6，IL12B和VDR基因多态性在间日疟原虫疟疾的严重程度，寄生虫血症和配子细胞减少症水平中的作用

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Objective: To investigate the influence of IL6, IL12B and VDR single nucleotide polymorphisms (SNPs) in uncomplicated Plasmodium vivax infection symptoms intensity, parasitemia and gametocytemia levels in a Brazilian Amazonian population. Methods: A total of 167 malaria patients infected by P. vivax have parasitemia and gametocytemia levels estimated before treatment. Fourteen clinical symptoms were evaluated and included in a principal component analysis to derive a clinical symptom index. Patients were genotyped for IL6-174C. >. G, IL12B 735T. >. C, 458A. >. G, 159A. >. C, and VDR FokI, TaqI, BsmI SNPs by Taqman 5' nuclease assays. A General Linear Model analysis of covariance with age, gender, exposure period and infection history and genetic ancestry was performed to investigate the association of genotypes with parasitemia and gametocytemia levels and with a clinical symptom index. Results: Higher parasitemia levels were observed in IL6-174C carriers (p= 0.02) whereas IL12B CGT haplotype carriers presented lower parasitemia levels (p= 0.008). VDR TaqIC/BsmIA haplotype carriers showed higher gametocyte levels than non-carriers (p= 0.013). Based on the clinical index values the IL6-174C. >. G polymorphism was associated with malaria severity. The IL6-174C carriers presented a more severe clinical index when compared to GG homozygotes (p= 0.001). Conclusion: The present study suggests that IL6, IL12 and VDR influence severity, parasitemia and gametocytemia clearance in P. vivax infections, and highlights their potential role in malaria immune response in an Amazonian population.
机译：目的：研究IL6，IL12B和VDR单核苷酸多态性（SNPs）对巴西亚马逊人群单纯性间日疟原虫感染症状强度，寄生虫血症和配子细胞减少症水平的影响。方法：总共167例间日疟原虫感染的疟疾患者在治疗前估计有寄生虫血症和配子体细胞减少症。评估了14种临床症状并将其包括在主成分分析中以得出临床症状指数。对患者进行IL6-174C基因分型。 >。 G，IL12B 735T。 >。 C，458A。 >。 G，159A。 >。 Taqman 5'核酸酶测定法检测C和VDR FokI，TaqI，BsmI SNP。进行了与年龄，性别，接触时间，感染史和遗传血统的协方差的通用线性模型分析，以研究基因型与寄生虫血症和配子体细胞减少症水平以及临床症状指数的关系。结果：在IL6-174C携带者中观察到较高的寄生虫血症水平（p = 0.02），而IL12B CGT单倍型携带者显示了较低的寄生虫血症水平（p = 0.008）。 VDR TaqIC / BsmIA单倍型载体显示出更高的配子细胞水平（p = 0.013）。基于临床指标值，IL6-174C。 >。 G多态性与疟疾的严重程度有关。与GG纯合子相比，IL6-174C携带者表现出更严重的临床指数（p = 0.001）。结论：本研究表明IL6，IL12和VDR影响间日疟原虫感染的严重程度，寄生虫血症和配子体细胞清除率，并强调了它们在亚马逊人群疟疾免疫反应中的潜在作用。

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