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Analysis of local and systemic TNF-α and IL1-α expression in the acute phase of knee osteoarthritis of rats

机译:大鼠膝骨关节炎急性期局部和全身TNF-α和IL1-α表达的分析

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摘要

To the Editor: TNFalpha and IL-1 play an important key role at the onset of osteoarthritis (OA) [1]. These pro inflammatory cytokines have a catabolic action and cause multiple articular effects on chondro-cytes, including the stimulation of matrix degradation proteinases and synthesis suppression of cartilage matrix [2-4]. The IL-1 family includes IL-1alpha and IL-1beta, according to that; it was proposed that IL-1alpha shows early degenerative changes, while IL-1beta appears in advanced OA [5].
机译:致编辑:TNFalpha和IL-1在骨关节炎(OA)发作中起着重要的关键作用[1]。这些促炎细胞因子具有分解代谢作用,并且对软骨细胞产生多种关节作用,包括刺激基质降解蛋白酶和抑制软骨基质的合成[2-4]。据此,IL-1家族包括IL-1α和IL-1β。有人提出,IL-1alpha表现出早期的退行性改变,而IL-1beta出现在晚期OA中[5]。

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