...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cytokine >An association between single nucleotide polymorphisms within TLR and TREM-1 genes and infective endocarditis
【24h】

An association between single nucleotide polymorphisms within TLR and TREM-1 genes and infective endocarditis

机译：TLR和TREM-1基因内的单核苷酸多态性与感染性心内膜炎之间的关联

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Infective endocarditis (IE) is an inflammatory condition of the lining of the heart chambers and valves, which is generally caused by bacteria. Toll-like receptors (TLRs) and Triggering receptor expressed on myeloid cells (TREMs) are key effectors of the innate system that play a significant role in the recognition of infectious agents, particularly, bacteria. We hypothesised that inherited variation in TLR and TREM-1 genes may affect individual susceptibility to IE. The distribution of genotypes and alleles of the TLR1 (rs5743551, rs5743611), TLR2 (rs3804099, rs5743708), TLR4 (rs4986790, rs4986791), TLR6 (rs3775073, rs5743810), and TREM-1 (rs1817537, rs3804277, rs6910730, rs7768162, rs2234246, rs4711668, rs9471535, rs2234237) gene polymorphisms was investigated in 110 Caucasian (Russian) subjects with IE and 300 age-, sex-, and ethnicity-matched healthy blood donors. Odds ratios with 95% confidence intervals were calculated. We found that C/C genotype of the rs3775073 polymorphism within TLR6 gene was associated with a decreased risk of IE (OR = 0.51, 95% CI = 0.26-0.97, P = 0.032) according to the recessive model; however, we observed no association between the other investigated SNPs within TLR and TREM-1 genes and IE. Further in-depth investigations in this field are necessary to shed the light on the impact of inherited variation within innate immune response genes on the development of IE. (C) 2014 Elsevier Ltd. All rights reserved.
机译：感染性心内膜炎（IE）是心脏腔和瓣膜的炎症状态，通常是细菌引起的。在髓样细胞（TREM）上表达的Toll样受体（TLR）和触发受体是先天系统的关键效应物，它们在识别传染原（尤其是细菌）中起着重要作用。我们假设TLR和TREM-1基因的遗传变异可能影响个体对IE的易感性。 TLR1（rs5743551，rs5743611），TLR2（rs3804099，rs5743708），TLR4（rs4986790，rs4986791），TLR6（rs3775073，rs5743810）和TREM-1（rs1817537，rs3802277，rs69816 ，rs4711668，rs9471535，rs2234237）基因多态性在110位具有IE和300位年龄，性别和种族相匹配的健康献血者的白种人（俄罗斯）受试者中进行了调查。计算出置信区间为95％的几率。根据隐性模型，我们发现TLR6基因内rs3775073多态性的C / C基因型与IE风险降低相关（OR = 0.51，95％CI = 0.26-0.97，P = 0.032）;但是，我们观察到TLR和TREM-1基因与IE中其他已调查的SNP之间没有关联。为了进一步了解先天免疫应答基因内遗传变异对IE发育的影响，有必要对该领域进行深入研究。 （C）2014 Elsevier Ltd.保留所有权利。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号