Humoral immune responses against the malaria vaccine candidate antigen Plasmodium vivax AMA-1 and IL-4 gene polymorphisms in individuals living in an endemic area of the Brazilian Amazon

Moreira Batista Tomaz Franciele Maira; da Cruz Furini Adriana Antonia; Capobianco Marcela Petrolini; Povoa Marinete Marins; Alves Trindade Pamella Cristina; Fraga Valeria Daltibari; Conceicao Luciana Moran; de Azevedo Lucas Ribeiro; Oliani Sonia Maria; Cassiano Gustavo Capatti; Cavasini Carlos Eugenio; Batista dos Santos Sidney Emanuel; Dantas Machado Ricardo Luiz

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Humoral immune responses against the malaria vaccine candidate antigen Plasmodium vivax AMA-1 and IL-4 gene polymorphisms in individuals living in an endemic area of the Brazilian Amazon

机译：居住在巴西亚马逊流行地区的个体对疟疾疫苗候选抗原间日疟原虫AMA-1和IL-4基因多态性的体液免疫反应

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Background: Several studies have recently demonstrated that the immune responses against malaria is governed by different factors, including the genetic components of the host. The IL-4 gene appears to be a strong candidate factor because of its role in the regulation of the Th2 response. The present study investigated the role of IL-4 polymorphisms in the development of IgG antibodies against PvAMA-1 and the IL-4 levels in individuals infected with Plasmodium vivax in a malaria endemic area in the Brazilian Amazon.

机译：背景：最近的一些研究表明，针对疟疾的免疫反应受不同因素控制，包括宿主的遗传成分。由于IL-4基因在调节Th2反应中的作用，因此它似乎是一个强大的候选因子。本研究调查了巴西亚马逊疟疾流行区间日疟原虫感染个体中IL-4多态性在针对PvAMA-1的IgG抗体的发展以及IL-4水平中的作用。

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来源
《Cytokine》 |2015年第2期|共6页
作者
Moreira Batista Tomaz Franciele Maira; da Cruz Furini Adriana Antonia; Capobianco Marcela Petrolini; Povoa Marinete Marins; Alves Trindade Pamella Cristina; Fraga Valeria Daltibari; Conceicao Luciana Moran; de Azevedo Lucas Ribeiro; Oliani Sonia Maria; Cassiano Gustavo Capatti; Cavasini Carlos Eugenio; Batista dos Santos Sidney Emanuel; Dantas Machado Ricardo Luiz;
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正文语种 eng
中图分类细胞生物学;
关键词
Plasmodium vivax; Interleukin 4; Ancestry informative markers; Parasitemia; SNP;

机译：间日疟原虫;白介素4;先祖信息标志物;寄生虫病;SNP;

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1. Humoral immune responses against the malaria vaccine candidate antigen Plasmodium vivax AMA-1 and IL-4 gene polymorphisms in individuals living in an endemic area of the Brazilian Amazon [J] . Moreira Batista Tomaz Franciele Maira, da Cruz Furini Adriana Antonia, Capobianco Marcela Petrolini, Cytokine . 2015,第2期

机译：居住在巴西亚马逊流行地区的个体对疟疾疫苗候选抗原间日疟原虫AMA-1和IL-4基因多态性的体液免疫反应
2. Cellular and humoral immune responses against the Plasmodium vivax MSP-1₁₉ malaria vaccine candidate in individuals living in an endemic area in north-eastern Amazon region of Brazil [J] . Evelyn KP Riccio, Paulo RR Totino, Lilian R Pratt-Riccio, Malaria Journal . 2013,第S1期

机译：居住在巴西东北亚马逊地区流行区的人对间日疟原虫MSP-1 _{19 疟疾候选疫苗的细胞和体液免疫反应}
3. Cellular and humoral immune responses against the Plasmodium vivax MSP-1₁₉ malaria vaccine candidate in individuals living in an endemic area in north-eastern Amazon region of Brazil [J] . Evelyn KP Riccio, Paulo RR Totino, Lilian R Pratt-Riccio, Malaria Journal . 2013,第S1期

机译：居住在巴西东北亚马逊地区流行区的人对间日疟原虫MSP-1 _{19 疟疾候选疫苗的细胞和体液免疫反应}
4. Surveillance of Humoral Immune Responses to Tuberculosis Glycolipid Antigen (TBGL) in TB and HIV Infected Individuals [C] . H. Ling, T. Hattori, H. X. Gu International AIDS Conference . 2004

机译：对TB和HIV感染个体抗原（TBG1）对肺结核糖脂抗原（TBG1）的监测
5. Evaluation of Plasmodium falciparum transmission blocking immunity induced by candidate vaccine antigens Pfs25 and Pfs48/45 and naturally induced immune responses in Zambian children. [D] . LeBlanc, Ralph E. 2009

机译：评价候选疫苗抗原Pfs25和Pfs48 / 45诱导的恶性疟原虫传播阻断免疫以及赞比亚儿童的自然诱导的免疫反应。
6. Cellular and humoral immune responses against the Plasmodium vivax MSP-119 malaria vaccine candidate in individuals living in a Brazilian endemic area in northeastern Amazon [O] . Evelyn Kety Pratt Riccio, Paulo Renato Rivas Totino, Irene Silva Soares, 2014

机译：生活在亚马逊东北部巴西流行区的个体对间日疟原虫MSP-119疟疾疫苗候选者的细胞和体液免疫反应
7. Cellular and humoral immune responses against the Plasmodium vivax MSP-119 malaria vaccine candidate in individuals living in an endemic area in north-eastern Amazon region of Brazil [O] . Riccio, Evelyn K, Totino, Paulo R, Pratt-Riccio, Lilian R, 2015

机译：居住在巴西东北亚马逊地区流行地区的个体对间日疟原虫MSP-119疟疾疫苗候选者的细胞和体液免疫反应
8. Phase 1/2a Study of the Malaria Vaccine Candidate Apical Membrane Antigen-1 (AMA-1) Administered in Adjuvant System AS01B or AS02A [R] . Spring, M. D., Cummings, J. F., Ockenhouse, C. F., 2009

机译：在辅助系统as01B或as02a中施用的疟疾疫苗候选顶端膜抗原-1（ama-1）的1 / 2a期研究

Humoral immune responses against the malaria vaccine candidate antigen Plasmodium vivax AMA-1 and IL-4 gene polymorphisms in individuals living in an endemic area of the Brazilian Amazon

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