Effect of IL-15 on the secretion of IL-1beta, IL-1Ra and sIL-1RII by PMN from cancer patients.

Jablonska E; mb.ac.bialystok.pl; Piotrowski L; Kiluk M; Jablonski J; Grabowska Z; Markiewicz W

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Effect of IL-15 on the secretion of IL-1beta, IL-1Ra and sIL-1RII by PMN from cancer patients.

机译：IL-15对癌症患者PMN分泌IL-1β，IL-1Ra和sIL-1RII的影响。

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In the present study, we demonstrate an effect of rhIL-15 on the simultaneous secretion of IL-1beta and its natural inhibitors IL-1Ra and sIL-1RII by human neutrophils isolated from normal and tumour-bearing hosts (oral cavity cancer and melanoma patients) compared with serum IL-15 levels. We found an rhIL-15 influence on IL-beta and IL-1Ra secreted by PMN from healthy controls. In contrast, the PMNs from cancer patients were not sensitive to rhIL-15 stimulation. However, we found a priming effect of rhIL-15 on IL-1beta production by LPS-stimulated cells in oral cavity cancer. We also found no effect on sIL-1RII release by PMN from cancer patients.

机译：在本研究中，我们证明了rhIL-15对分离自正常和荷瘤宿主（口腔癌和黑色素瘤患者）的人嗜中性粒细胞同时分泌IL-1beta及其天然抑制剂IL-1Ra和sIL-1RII的作用）与血清IL-15水平进行比较。我们发现rhIL-15对健康对照组PMN分泌的IL-β和IL-1Ra的影响。相反，来自癌症患者的PMN对rhIL-15刺激不敏感。然而，我们发现在口腔癌中，rhIL-15对LPS刺激的细胞产生IL-1beta产生了启动作用。我们还发现PMN对癌症患者的sIL-1RII释放没有影响。

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《Cytokine》 |2001年第5期|共5页
作者
Jablonska E; mb.ac.bialystok.pl; Piotrowski L; Kiluk M; Jablonski J; Grabowska Z; Markiewicz W;
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正文语种 eng
中图分类细胞生物学;
关键词
Interleukin-1; Interleukin-15; Neutrophils; Receptors; Interleukin-1; Sialoglycoproteins; 白细胞介素1; 白细胞介素15; 中性白细胞; 受体; 白细胞介素1; 唾液糖蛋白类;

机译：Interleukin-1;Interleukin-15;Neutrophils;Receptors;Interleukin-1;Sialoglycoproteins;白细胞介素1;白细胞介素15;中性白细胞;受体;白细胞介素1;唾液糖蛋白类;

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1. Effect of IL-15 on the secretion of IL-1beta, IL-1Ra and sIL-1RII by PMN from cancer patients. [J] . Jablonska E, mb.ac.bialystok.pl, Piotrowski L, Cytokine . 2001,第5期

机译：IL-15对癌症患者PMN分泌IL-1β，IL-1Ra和sIL-1RII的影响。
2. Effects of plaque, psychological stress and gender on crevicular Il-1beta and Il-1ra secretion. [J] . Waschul B, Herforth A, Stiller Winkler R, Journal of clinical periodontology . 2003,第3期

机译：斑块，心理压力和性别对小泡Il-1beta和Il-1ra分泌的影响。
3. SCF, IL-1beta, IL-1ra and GM-CSF in the bone marrow and serum of normal individuals and of AML and CML patients. [J] . Tao M, Li B, Nayini J, Cytokine . 2000,第6期

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5. Lysosomal destabilization in retinal pigment epithelial cells activates the NLRP3 inflammasome and induces IL-1beta secretion. [D] . Tseng, Wen Allen. 2014

机译：视网膜色素上皮细胞中的溶酶体去稳定化激活NLRP3炎性小体并诱导IL-1β分泌。
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Effect of IL-15 on the secretion of IL-1beta, IL-1Ra and sIL-1RII by PMN from cancer patients.

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