A20 inhibits NF-kappa B activation downstream of multiple Map3 kinases and interacts with the I kappa B signalosome.

Zetoune FS; Murthy AR; Shao Z; Hlaing T; Zeidler MG; Li Y; Vincenz C

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A20 inhibits NF-kappa B activation downstream of multiple Map3 kinases and interacts with the I kappa B signalosome.

机译：A20抑制多种Map3激酶下游的NF-κB活化，并与IκB信号体相互作用。

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A20, a TNF inducible gene, inhibits TNF-mediated apoptosis as well as NF-kappa B induced by this cytokine. Reporter assay experiments revealed that A20 is a very effective inhibitor of NF-kappa B signaling induced by TRAFs and several Map3 kinases, including NIK, MEKK1, COT, and TAK1. Similarly, the NF-kappa B inducing activity of TAX, an activator of the I kappa B kinase complex, is also abrogated by A20. Inhibition of NF-kappa B is specific as A20 has no effect on TNF-alpha-induced JNK activation. These results suggest that the molecular target of A20 is more distal to the receptor than TRAFs as previously proposed. A20 inhibits NF-kappa B-dependent transcription without a concomitant decrease in nuclear NF-kappa B DNA binding activity or nuclear translocation of p65. This apparent discrepancy between transcriptional readout and gel shift experiments is observed with a variety of stimuli, including expression of IKK beta. Therefore, in addition to the phosphorylation of I kappa B, another signal is needed for transcriptional activation of NF-kappa B. A20 inhibits this non-redundant signal. The observation that A20 associates with IKK alpha and is phosphorylated upon IKK beta co-expression may suggest that A20 interferes with some aspects of signalosome function. Copyright 2001 Academic Press.

机译：TNF诱导基因A20抑制TNF介导的细胞凋亡以及该细胞因子诱导的NF-κB。记者分析实验表明，A20是TRAF和几种Map3激酶（包括NIK，MEKK1，COT和TAK1）诱导的NF-κB信号传导的非常有效的抑制剂。类似地，A20也废除了TAX（IκB激酶复合物的活化剂）的NF-κB诱导活性。 NF-κB的抑制是特异性的，因为A20对TNF-α诱导的JNK激活没有影响。这些结果表明，与之前提出的TRAF相比，A20的分子靶标距离受体更远。 A20抑制NF-κB依赖性转录，而不伴随核NF-κBDNA结合活性或p65核移位降低。在包括IKK beta表达在内的多种刺激下，转录读数与凝胶位移实验之间存在明显的差异。因此，除了IκB的磷酸化，还需要另一个信号来激活NF-κB的转录。A20抑制该非冗余信号。 A20与IKK alpha关联并在IKK beta共表达时被磷酸化的观察结果可能表明A20会干扰信号体功能的某些方面。版权所有2001，学术出版社。

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《Cytokine》 |2001年第6期|共17页
作者
Zetoune FS; Murthy AR; Shao Z; Hlaing T; Zeidler MG; Li Y; Vincenz C;
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正文语种 eng
中图分类细胞生物学;
关键词
Mitogen Activated Protein Kinases metabolism; NF-kappa B; Proteins; NF-κB; 蛋白质类;

机译：Mitogen Activated Protein Kinases metabolism;NF-kappa B;Proteins;NF-κB;蛋白质类;

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1. A20 inhibits NF-kappa B activation downstream of multiple Map3 kinases and interacts with the I kappa B signalosome. [J] . Zetoune FS, Murthy AR, Shao Z, Cytokine . 2001,第6期

机译：A20抑制多种Map3激酶下游的NF-κB活化，并与IκB信号体相互作用。
2. Ras, protein kinase C zeta, and I kappa B kinases 1 and 2 are downstream effectors of CD44 during the activation of NF-kappa B by hyaluronic acid fragments in T-24 carcinoma cells. [J] . Fitzgerald KA, Bowie AG, Skeffington BS, The Journal of Immunology: Official Journal of the American Association of Immunologists . 2000,第4期

机译：Ras，蛋白激酶C zeta和IκB激酶1和2是透明质酸片段在T-24癌细胞中激活NF-κB期间CD44的下游效应子。
3. The inhibitor ABIN-2 disrupts the interaction of receptor-interacting protein with the kinase subunit IKK gamma to block activation of the transcription factor NF-kappa B and potentiate apoptosis [J] . Liu WK, Yen PF, Chien CY, The Biochemical Journal . 2004,第Pta3期

机译：抑制剂ABIN-2破坏受体相互作用蛋白与激酶亚基IKKγ的相互作用，从而阻断转录因子NF-κB的活化并增强细胞凋亡
4. Myristoylation of Protein Kinase C Beta II/Zeta Peptide Inhibitors, or Caveolin-1 Peptide Facilitates Rapid Attenuation of Phorbol 12-Myristate 13-Acetate (PMA) or N-Formyl-L- Methionyl-L-Leucyl-L-Phenylalanine (fMLP) Activated Leukocyte Superoxide Release [C] . Kerry-Anne A. Perkins, Kyle Bartol, Qian Chen American Peptide Symposium . 2011

机译：蛋白质激酶CβII/ Zeta肽抑制剂的MyRistoylation，或Caveolin-1肽促进了摇骨12-镁素13-乙酸酯（PMA）或N-甲酰基-1-甲硫基-L-Leucyl-L-苯丙氨酸（FMLP）的快速衰减活化白细胞超氧化物释放
5. Molecular mechanism of inhibitor of kappa B kinase (IKK) complex activation by inducible phosphorylation and ubiquitination upon T cell receptor (TCR) stimulation. [D] . Shambharkar, Prashant. 2007

机译：在T细胞受体（TCR）刺激下，可诱导的磷酸化和泛素化作用抑制kappa B激酶（IKK）复合物激活的分子机制。
6. Lactobacillus helveticus SBT2171 Induces A20 Expression via Toll-Like Receptor 2 Signaling and Inhibits the Lipopolysaccharide-Induced Activation of Nuclear Factor-kappa B and Mitogen-Activated Protein Kinases in Peritoneal Macrophages [O] . Michio Kawano, Masaya Miyoshi, Tadaaki Miyazaki -1

机译：瑞士乳杆菌SBT2171通过Toll样受体2信号传导诱导A20表达并抑制脂多糖诱导的腹膜巨噬细胞中核因子-κB和丝裂原活化蛋白激酶的活化。
7. The inhibitor ABIN-2 disrupts the interaction of receptor-interacting protein with the kinase subunit IKK gamma to block activation of the transcription factor NF-kappa B and potentiate apoptosis [O] . Liu, WK 2008

机译：抑制剂ABIN-2破坏受体相互作用蛋白与激酶亚基IKKγ的相互作用，从而阻断转录因子NF-κB的活化并增强细胞凋亡
8. A20 Functional Domains Regulate Subcellular Localization and NF-Kappa B Activation. [R] . Washington, M. A. 2013

机译：a20功能域调节亚细胞定位和NF-κB活化。

A20 inhibits NF-kappa B activation downstream of multiple Map3 kinases and interacts with the I kappa B signalosome.

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