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首页> 外文期刊>Biochimica et biophysica acta. Biomembranes >Gap junction proteins are key drivers of endocrine function
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Gap junction proteins are key drivers of endocrine function

机译：间隙结蛋白是内分泌功能的关键驱动因素

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Abstract It has long been known that the main secretory cells of exocrine and endocrine glands are connected by gap junctions, made by a variety of connexin species that ensure their electrical and metabolic coupling. Experiments in culture systems and animal models have since provided increasing evidence that connexin signaling contributes to control the biosynthesis and release of secretory products, as well as to the life and death of secretory cells. More recently, genetic studies have further provided the first lines of evidence that connexins also control the function of human glands, which are central to the pathogenesis of major endocrine diseases. Here, we summarize the recent information gathered on connexin signaling in these systems, since the last reviews on the topic, with particular regard to the pancreatic beta cells which produce insulin, and the renal cells which produce renin. These cells are keys to the development of various forms of diabetes and hypertension, respectively, and combine to account for the exploding, worldwide prevalence of the metabolic syndrome. This article is part of a Special Issue entitled: Gap Junction Proteins edited by Jean Claude Herve. Highlights ? Connexins couple the cells of all endocrine glands ? Connexins often change with hormone secretion ? Cx36 modulates insulin secretion and survival of pancreatic β-cells ? Loss of Cx36 causes β-cell alterations typical of diabetes ? A SNP decreases Cx36 expression in diabetic patients ? Cx40 modulates renin secretion by epithelo?d renal cells ? Loss of Cx40 induces renin-dependent hypertension ? Cx40 mutations associate with forms of human hypertension
机译：摘要已经众所周知，外分泌和内分泌腺的主要分泌细胞通过间隙连接连接，由各种Connexin物种制成，确保其电气和代谢偶联。培养系统和动物模型的实验已经提供了越来越多的证据，即Connexin信号传导有助于控制生物合成和分泌产物的生物合成和释放，以及分泌细胞的生命和死亡。最近，遗传学研究进一步提供了第一阶的证据，即Connexins还控制了人体腺体的功能，这是主要内分泌疾病的发病机制的核心。在这里，我们总结了最近在这些系统中收集了Connexin信号传导的信息，自上次关于该主题的评论，特别是产生胰岛素的胰腺β细胞和产生肾素的肾细胞。这些细胞分别为各种形式的糖尿病和高血压的开发的关键，并结合到爆炸，全世界的代谢综合征患病率。本文是题为的特殊问题的一部分：Jean Claude Herve编辑的Gap Junction蛋白。强调 ？ Connexins耦合所有内分泌腺的细胞？ Connexins经常用激素分泌改变？ CX36调节胰岛素分泌和胰腺β细胞的存活？ CX36的丧失会导致β-细胞改变典型的糖尿病？ SNP降低糖尿病患者的CX36表达？ CX40通过上皮细胞调节肾素分泌物吗？ CX40的丧失诱导肾内依赖性高血压？ CX40突变与人的高血压形式相关联

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