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首页> 外文期刊>Biochimica et biophysica acta. Biomembranes >Mechanisms of pannexin1 channel gating and regulation
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Mechanisms of pannexin1 channel gating and regulation

机译：Pannexin1通道门控和调节机制

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摘要

Abstract Pannexins are a family of integral membrane proteins with distinct post-translational modifications, sub-cellular localization and tissue distribution. Panx1 is the most studied and best-characterized isoform of this gene family. The ubiquitous expression, as well as its function as a major ATP release and nucleotide permeation channel, makes Panx1 a primary candidate for participating in the pathophysiology of CNS disorders. While many investigations revolve around Panx1 functions in health and disease, more recently, details started emerging about mechanisms that control Panx1 channel activity. These advancements in Panx1 biology have revealed that beyond its classical role as an unopposed plasma membrane channel, it participates in alternative pathways involving multiple intracellular compartments, protein complexes and a myriad of extracellular participants. Here, we review recent progress in our understanding of Panx1 at the center of these pathways, highlighting its modulation in a context specific manner. This article is part of a Special Issue entitled: Gap Junction Proteins edited by Jean Claude Herve Highlights ? Comprehensive review of recent advancement of Panx1 biology ? Focus on Panx1 channel regulation ? Discussion of conflicts in the field
机译：摘要Pannexins是一种整体膜蛋白质，具有不同的翻译后修饰，亚细胞定位和组织分布。 Panx1是该基因家族最熟练和最表征的同种型。普遍存在的表达以及其作为主要ATP释放和核苷酸渗透通道的功能使PANX1成为参与CNS疾病病理生理学的主要候选者。虽然许多调查围绕Panx1在健康和疾病的功能周围旋转，但最近，在控制Panx1信道活动的机制中开始提供细节。 Panx1生物学的这些进步揭示了超越其作为未羽毛的血浆膜通道的经典作用，它参与涉及多个细胞内隔室，蛋白质复合物和细胞外参与者的替代途径。在这里，我们审查了我们对这些途径中心的PANX1的理解的最新进展，以语境特定方式突出显示其调制。本文是题为特殊问题的一部分：Jean Claude Herve Explights编辑的Gap Junction蛋白质？综合审查PanX1生物学近期进步？专注于Panx1渠道规则？讨论现场冲突

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