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首页> 外文期刊>Biochimica et biophysica acta. Biomembranes >Altered lipid properties of the stratum corneum in Canine Atopic Dermatitis
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Altered lipid properties of the stratum corneum in Canine Atopic Dermatitis

机译：改变了犬特应性皮炎中角质层的脂质特性

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Abstract Skin barrier disruption plays a role in the pathogenesis of atopic dermatitis (AD) in humans. However, little is known about skin barrier (dys-) function in Canine Atopic Dermatitis. The properties of lipids located in the outermost layer of the skin, the stratum corneum (SC) are considered to be important for the barrier. In the present study the lipid composition and lipid organization of the SC of AD dogs and control dogs were examined. The lipid composition of lesional AD skin as compared to control skin, showed a reduced free fatty acid level and a decreased ratio of ceramide[NS] C44/C34, in which C44 and C34 are the total numbers of carbon atoms of the sphingosine (S) and non-hydroxy (N) acyl chains. As a consequence of the observed changes in lipid composition in AD lesional skin the lamellar organization of lipids altered and a shift from orthorhombic to hexagonal lipid packing was monitored. Simultaneously an increased conformational disordering occurred. These changes are expected to compromise the integrity of the skin barrier. The C44/C34 chain length ratio of ceramide[NS] also showed a decreasing nonlinear relationship with the AD severity score (CADESI). Taken together, canine atopic skin showed alterations in SC lipid properties, similar to the changes observed in atopic dermatitis in humans, that correlated with a disruption of the skin barrier. Hence lipids play an important role in the pathogenesis of Canine Atopic Dermatitis. Graphical abstract Partly adapted from the figure originally published in Journal of Lipid Research. Janssens et al. Increase in short-chain ceramides correlates with an altered lipid organization and decreased barrier function in atopic eczema patients. Journal of Lipid Research . 2012; 53 (12), 2755–2766. ? the American Society for Biochemistry and Molecular Biology. Display Omitted Highlights ? Focus on stratum corneum lipid composition and organization in Canine Atopic Dermatitis ? Fatty acid level decreased and ceramide[NS] C34 increased in lesional skin. ? Altered lamellar organization and conformational disordering prominent in lesional skin ? Chain length distribution of ceramide[NS] C44/C34 correlated to disease severity
机译：摘要皮肤屏障中断在人类特应性皮炎（AD）的发病机制中起着作用。然而，很少有关于犬特应性皮炎的皮肤屏障（Dys-）功能。位于皮肤的最外层的脂质的性质，地层胚层（SC）被认为对屏障很重要。在本研究中，检查了AD狗和对照犬SC的脂质组合物和脂质组织。与对照皮肤相比，损伤患者的脂质组合物，显示出可减少的游离脂肪酸水平和神经酰胺[NS] C44 / C34的减少比例，其中C44和C34是鞘氨醇的碳原子的总数（S.） ）和非羟基（n）酰基链。由于观察到的脂质组合物中的脂质组合物中的变化，监测脂质的层状组织改变，并监测从正晶脂填料的偏移的偏移。同时发生了增加的构象失调。这些变化预计会损害皮肤屏障的完整性。 Cyamide [NS]的C44 / C34链长比还显示出与AD严重程度（CADESI）的非线性关系降低。一起携带，犬的特应性皮肤显示出SC脂质特性的改变，类似于人类特应性皮炎中观察到的变化，与皮肤屏障的破坏相关。因此，脂质在犬犬特应性皮炎的发病机制中发挥着重要作用。图形摘要部分适应了最初在脂质研究杂志中发表的图。 Janssens等人。短链神经酰胺的增加与改变的脂质组织相关，并在特应性湿疹患者中降低屏障功能。荔枝研究杂志。 2012; 53（12），2755-2766。还美国生物化学和分子生物学学会。显示省略亮点？专注于犬特应性皮炎中的角质层脂质组合物和组织吗？脂肪酸水平降低，神经酰胺[NS] C34在损害皮肤中增加。还改变的层状组织和损害皮肤突出的构象性交突出？神经酰胺的链长分布[ns] c44 / c34与疾病严重程度相关

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