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首页> 外文期刊>Cytokine & growth factor reviews >IkappaB kinase beta (IKKbeta/IKK2/IKBKB)--a key molecule in signaling to the transcription factor NF-kappaB.
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IkappaB kinase beta (IKKbeta/IKK2/IKBKB)--a key molecule in signaling to the transcription factor NF-kappaB.

机译：IkappaB激酶beta（IKKbeta / IKK2 / IKBKB）-信号转导转录因子NF-kappaB的关键分子。

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摘要

IKKbeta/IKBKB (IkappaB kinase beta), also designated as IKK2, was named after its function of phosphorylating IkappaB molecules, the inhibitors of NF-kappaB transcription factors. The kinase activity of IKKbeta targets two adjacent serine residues of IkappaB leading to ubiquitination and proteasomal degradation of the inhibitor, followed by release and activation of NF-kappaB. Many signaling pathways that activate NF-kappaB converge at the level of IKKbeta. Examples of stimuli leading to IKKbeta and subsequent NF-kappaB activation include inflammatory cytokines (IL-1, TNFalpha), endotoxins (lipopolysaccharide), viral infection and double strand RNA as well as physical signals such as UV-irradiation. Transcription factors of the NF-kappaB protein family have a great variety of functions in regulating the immune system, cellular differentiation, survival and proliferation. NF-kappaB is an essential factor in acute as well as chronic inflammation, a pathological state which is either cause or co-factor ina great variety of diseases. Moreover, recent data suggest that many variants of cancer are characterized by elevated constitutive activity of NF-kappaB, which can act as a survival factor for malignant cells by its predominantly anti-apoptotic function. Given the tight regulation of NF-kappaB by IkappaB molecules and the central role of IKKbeta in phosphorylation and degradation of the inhibitor, IKKbeta is a very promising target for pharmaceutical substances aiming at interfering with NF-kappaB activation.
机译：IKKbeta / IKBKB（IkappaB激酶beta）也称为IKK2，以其磷酸化IkappaB分子（NF-kappaB转录因子的抑制剂）的功能命名。 IKKbeta的激酶活性靶向IkappaB的两个相邻丝氨酸残基，导致抑制剂的泛素化和蛋白酶体降解，随后释放和激活NF-kappaB。激活NF-κB的许多信号通路在IKKbeta的水平上收敛。导致IKKbeta和随后的NF-κB活化的刺激物包括炎性细胞因子（IL-1，TNFα），内毒素（脂多糖），病毒感染和双链RNA以及诸如紫外线照射的物理信号。 NF-κB蛋白家族的转录因子在调节免疫系统，细胞分化，存活和增殖中具有多种功能。 NF-κB是急性和慢性炎症的必要因素，而急性炎症是多种疾病的起因或辅助因素。此外，最近的数据表明，许多癌症变体的特征在于NF-κB的组成活性升高，而NF-κB可以通过其主要的抗凋亡功能充当恶性细胞的生存因子。鉴于IkappaB分子对NF-kappaB的严格调控以及IKKbeta在抑制剂的磷酸化和降解中的核心作用，IKKbeta是旨在干扰NF-kappaB活化的药物的非常有希望的靶标。

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