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首页> 外文期刊>Bioanalysis >Magnetic solid-phase extraction coupled with UHPLC–MS/MS for four antidepressants and one metabolite in clinical plasma and urine samples
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Magnetic solid-phase extraction coupled with UHPLC–MS/MS for four antidepressants and one metabolite in clinical plasma and urine samples

机译：磁性固相提取与UHPLC-MS / MS进行四个抗抑郁药和临床血浆和尿液样品的一个代谢物

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Aim: Routine therapeutic drug monitoring is highly recommended since common antidepressant combinations increase the risk of drug–drug interactions or overlapping toxicity. Materialsandmethods: A magnetic solid-phase extraction by using C18-functionalized magnetic silica nanoparticles (C18-Fe3O4@SiO2 NPs) as sorbent was proposed for rapid extraction of venlafaxine, paroxetine, fluoxetine, norfluoxetine and sertraline from clinical plasma and urine samples followed by ultra-HPLC–MS/MS assay. Results:?The synthesized C18-Fe3O4@SiO2 NPs showed high magnetization and efficient extraction for the analytes. After cleanup by magnetic solid-phase extraction, no matrix effects were found in plasma and urine matrices. The analytes showed LODs among 0.15–0.75?ng ml-1, appropriate linearity (R?≥?0.9990) from 2.5 to 1000?ng ml-1, acceptable accuracies 89.1–110.9% with precisions?≤11.0%.?The protocol was successfully applied for the analysis of patients’ plasma and urine samples. Conclusion: It shows high potential in routine therapeutic drug monitoring of clinical biological samples.
机译：目的：强烈推荐常规治疗药物监测，因为常见的抗抑郁组合增加药物 - 药物相互作用或重叠毒性的风险。方法是：使用C18官能化磁性二氧化硅纳米粒子（C18-Fe3O4 @ SiO 2 NPS）作为吸附剂的磁性相萃取，从临床血浆和尿液样本中快速提取Venlafaxine，Paroxetine，Flyoxetine，Norfluoxetine和塞拉氏萘胺，然后是超级-HPLC-MS / MS测定。结果：1：合成的C18-Fe3O4 @ SiO2 NPS显示出对分析物的高磁化和有效的提取。通过磁共相萃取清除后，在血浆和尿基质中没有发现基质效应。分析物在0.15-0.75？ng ml-1之间显示腰层，适当的线性度（r？≥≤0.9990），从2.5到1000？ng ml-1，可接受的精度89.1-110.9％，精确的尺寸≤11.0％。？该协议是成功应用于患者血浆和尿液样本的分析。结论：临床生物样品的常规治疗药物监测中显示出高潜力。

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