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Quantification of eicosanoids and their metabolites in biological matrices: a review

机译：在生物学矩阵中的七卤代醇及其代谢物的定量：综述

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The quantification of eicosanoids and their metabolites in biological samples remain an analytical challenge, even though a number of methodologies/techniques have been developed. The major difficulties encountered are related to the oxidation of eicosanoids and their low quantities in biological matrices. Among the known methodologies, liquid chromatography-mass spectrometry (LC-MS/MS) is the standard method for eicosanoid quantification in biological samples. Recently advances have improved the ability to identify and simultaneous quantitate eicosanoids in biological matrices. The present article reviews the quantitative analysis of eicosanoids in different biological matrices by LC and ultra performance liquid chromatography (UPLC)-MS/MS and discusses important aspects to be considered during the collection, sample preparation and the generation of calibration curves required for eicosanoid analysis.
机译：即使已经开发了许多方法/技术，生物样品中的七淀粉样品及其代谢物的定量仍然是分析攻击。 遇到的主要困难与七硅烷醇的氧化和它们在生物基质中的少量有关。 在已知的方法中，液相色谱 - 质谱（LC-MS / MS）是生物样品中的果香烷定量的标准方法。 最近进步改善了在生物学基质中鉴定和同时定量卓越量的能力。 本文综述了LC和超高效液相色谱（UPLC）/ MS在不同生物学基质中的七氰化物的定量分析，并讨论了在逐渐分析所需的校准曲线期间考虑的重要方面 。

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