...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Burns: Including Thermal Injury >The use of collagen-based matrices in the treatment of full-thickness wounds
【24h】

The use of collagen-based matrices in the treatment of full-thickness wounds

机译：基于胶原基矩阵在治疗全厚伤口时

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Chronic and complex full-thickness wounds have become increasingly prevalent. Besides autologous skin transplantation, innovative wound dressing products have gained interest, as the functional and esthetic outcome is still limited. In this respect, the effect of a novel modifiable collagen-gelatin fleece on the healing of deep dermal wounds was examined and compared with untreated controls and Matriderm (R). A total of 48 full-thickness skin defects were generated on six minipigs and treated with the novel collagen-gelatin fleece of different thicknesses in single or multiple application (n = 36) or treated with Matriderm (R) in a single application (n = 6), or the wounds were left untreated (n = 6). Wound healing was analyzed planimetrically by wound closure per time and histologically with regard to epidermal thickness and cell density. Compared to untreated wounds, wound closure per time and histological skin quality with regard to the mean epidermal thickness and epidermal cell amount were enhanced in both treatment groups. Overall, the best results for the novel collagen-gelatin fleece were achieved for multiple applications with a thickness of 150 g/m(2). The novel biomaterial shows accelerated and improved dermal wound repair in a minipig model. As the manufacturing process of the scaffold allows the integration of bioactive substances such as antibiotics and growth factors, we intend to design a composite biomaterial using this scaffold as a carrier matrix. (C) 2016 Elsevier Ltd and ISBI. All rights reserved.
机译：慢性和复杂的全厚伤口越来越普遍。除了自体皮肤移植外，创新的伤口敷料产品也获得了兴趣，因为功能和美学结果仍然有限。在这方面，研究了一种新型可变性胶原蛋白 - 明胶羊毛对深皮肤伤愈合的影响，并与未处理的对照和MITRIDERM（R）进行比较。在六种微量化上产生了48个全厚的皮肤缺陷，并用单一或多个施用（n = 36）的不同厚度的新型胶原蛋白 - 明胶羊毛处理，或用单个应用中的MITRIDERM（R）处理（n = 6），或者伤口未经处理（n = 6）。通过每次伤口闭合并在表皮厚度和细胞密度方面通过伤口闭合分析伤口愈合。与未经处理的伤口相比，在两种治疗组中，每次伤口闭合和组织学皮肤质量方面的平均表皮厚度和表皮细胞量得到增强。总的来说，对于多种厚度为150g / m（2）的多种应用，实现了新型胶原蛋白 - 明胶羊毛的最佳效果。新型生物材料显示MINIPIG模型中的加速和改善的皮肤伤口修复。由于支架的制造过程允许整合生物活性物质，例如抗生素和生长因子，我们打算使用该支架作为载体基质设计复合生物材料。 （c）2016年Elsevier Ltd和Isbi。版权所有。

著录项

  • 来源
    《Burns: Including Thermal Injury》 |2016年第6期|共8页
  • 作者

    Petersen Wiebke; Rahmanian-Schwarz Afshin; Werner Jan-Ole; Schiefer Jennifer; Rothenberger Jens; Huebner Gunnar; Schaller Hans-Eberhard; Held Manuel;

  • 作者单位

    Univ Tubingen Dept Plast Reconstruct Hand &

    Burn Surg BG Trauma Ctr Tubingen Germany;

    Univ Witten Herdecke Helios Clin Wuppertal GmbH Dept Plast Hand Reconstruct &

    Aesthet Surg;

    Univ Tubingen Univ Hosp Tuebingen Med Ctr 2 Dept Med Oncol &

    Hematol Otfried Muller Str 10 D;

    Univ Tubingen Dept Plast Reconstruct Hand &

    Burn Surg BG Trauma Ctr Tubingen Germany;

    Univ Tubingen Dept Plast Reconstruct Hand &

    Burn Surg BG Trauma Ctr Tubingen Germany;

    Univ Witten Herdecke Helios Clin Wuppertal GmbH Dept Plast Hand Reconstruct &

    Aesthet Surg;

    Univ Tubingen Dept Plast Reconstruct Hand &

    Burn Surg BG Trauma Ctr Tubingen Germany;

    Univ Tubingen Dept Plast Reconstruct Hand &

    Burn Surg BG Trauma Ctr Tubingen Germany;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 创伤外科学;
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号