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首页> 外文期刊>British Journal of Clinical Pharmacology >Incidence and risk factors for hyponatraemia following treatment with fluoxetine or paroxetine in elderly people.
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Incidence and risk factors for hyponatraemia following treatment with fluoxetine or paroxetine in elderly people.

机译：氟西汀或帕罗西汀治疗老年人治疗后低钠血症的发病率和危险因素。

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AIMS: To establish the incidence, time course and risk factors of hyponatraemia complicating treatment with fluoxetine or paroxetine in an elderly population. METHODS: Retrospective descriptive and case control study in an inpatient/outpatient assessment and rehabilitation service for people aged 65 years and over. Fourteen elderly patients with hyponatraemia complicating treatment with fluoxetine or paroxetine, matched with 56 controls drawn from 845 patients treated with fluoxetine or paroxetine over 3.5 years. No other SSRI antidepressants were used over the study period. RESULTS: The incidence of hyponatraemia was 4.7/1000 people treated/year (6.3/1000 for fluoxetine and 3.5/1000 for paroxetine). Hyponatraemia was detected at a median 13.5 (mean 18.6, range 4-64) days after commencing the drug. Mean (95% confidence intervals) body weights were lower in cases at 53.0 (95% CI 46.5-59.5) kg compared with controls at 64.5 (95% CI 60.1-68.4) kg (P<0.01). 71% of cases were women compared with 45% of controls (P=0.07) but the effect of gender was confounded by body weight. There were trends for cases to be older (odds ratio 1.10: 95% CI 0.99, 1.23) and lighter (odds ratio 0.92, 95% CI 0.86, 0.99). CONCLUSIONS: Approximately 1 in 200 elderly people treated per year with fluoxetine or paroxetine developed complicating hyponatraemia. Low body weight was a particular risk factor. Most cases occurred within 3 weeks of treatment.
机译：目的：建立低钠血症的发病率，时间课程和富含氟西汀或帕罗西汀在老年人口中的治疗。方法：对65岁及以上人民的住院/门诊评估和康复服务的回顾性描述性和案例控制研究。十四名老年人患有过度低估的患者，使氟西汀或帕罗西汀治疗复杂化，与345名患者绘制的56例对照，氟西汀或帕罗西汀的845名患者均为3.5岁。在研究期间没有使用其他SSRI抗抑郁药。结果：低钠血症的发生率为4.7 / 1000人治疗/年（氟西汀6.3 / 1000，帕罗西汀的3.5 / 1000）。在开始药物后，在中位数13.5（平均18.6，范围4-64）天中检测到低钠血症。平均值（95％置信区间）体重在53.0（95％CI 46.5-59.5）kg与64.5（95％CI 60.1-68.4）Kg（P <0.01）相比的情况下较低。 71％的案件是女性与45％的对照（P = 0.07）相比（P = 0.07），但性别的效果被体重混淆。较旧的病例有趋势（差距1.10：95％CI 0.99,1.23）和更轻（差距比0.92,95％CI 0.86,0.99）。结论：每年约有1例每年治疗氟西汀或帕罗西汀的1名老年人开发了复杂的低钠血症。低体重是特定的危险因素。大多数病例发生在3周内治疗。

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