...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Best practice & research:Clinical obstetrics & gynaecology >The natural history of human papillomavirus infection
【24h】

The natural history of human papillomavirus infection

机译：人乳头瘤病毒感染的自然历史

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Human papillomavirus (HPV) is a small double-stranded DNA virus that commonly infects humans. The oncogenic characteristics of HPV derive from the oncoproteins E6 and E7 that act inhibiting p53 and pRB tumor suppressors. About 5% of all cancers world-wide are attributable mainly to those known as high-risk, including. HPV types 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, and 59. Infection with HPV is common after sexual initiation, but the majority of HPV infections do not cause symptoms or disease and are cleared within 12-24 months post-infection. Only a small fraction of those infections that persist or progress to a preneo-plastic lesion result in cancer. Persistence of HPV infection is needed to start the oncogenic process. Clearance of infection is common in young adults. Viral load and viral type are the main cofactors for progression from infection to cervical intraepithelial lesions and cancer. Smoking, hormonal exposure, and HIV are additional exposures that increase the risk of progression to cancer. The adverse health effects of HPV infections can be largely controlled through vaccination and screening. (C) 2017 Published by Elsevier Ltd.
机译：人乳头瘤病毒（HPV）是一种小型双链DNA病毒，通常感染人类。 HPV的致癌特性来自癌蛋白E6和E7，即作用抑制p53和PRB肿瘤抑制剂。大约5％的全球癌症占所有癌症，主要是被称为高风险的人，包括。 HPV类型16,18,31,33,35,39,45,51,52,56,58和59.性能发生后，HPV是常见的，但大多数HPV感染不会引起症状或疾病在感染后12-24个月内清除。只有一小部分这些感染，持续或进展到普通塑料病变导致癌症。需要HPV感染的持久性来开始致癌过程。感染清除在年轻人中是常见的。病毒载荷和病毒型是来自感染到宫颈上皮内病变和癌症的进展的主要辅因子。吸烟，荷尔蒙暴露和艾滋病毒是额外的暴露，从而增加了对癌症进展的风险。 HPV感染的不良健康效应可以通过疫苗接种和筛选来大大控制。 （c）2017年由elestvier有限公司出版

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号