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Female fertility preservation in the pediatric and adolescent cancer patient population

机译:女性生育保存在儿科和青少年癌症患者人口中

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The 5-year survival rate for childhood cancer is over 80%, thereby increasing the number of young women facing infertility in the future because of the gonadotoxic effects of chemotherapy and radiation. The gonadotoxic effects of childhood cancer treatment vary by the radiation regimen and the chemotherapeutic drugs utilized. Although the American Society of Clinical Oncology guidelines recommend fertility preservation for all patients, there are several barriers and ethical considerations to fertility preservation in the pediatric and adolescent female population. Additionally, the fertility preservation methods for pre- and postpubertal females differ, with only experimental methods available for prepubertal females. We will review the risk of chemotherapy and radiation on female fertility, the approach to fertility preservation in the pediatric and adolescent female population, methods of fertility preservation for both pre- and postpubertal females, barriers to fertility preservation, cost, and psychological and ethical considerations. (C) 2018 Elsevier Ltd. All rights reserved.
机译:儿童癌症的5年生存率超过80%,从而增加了未来不孕症的年轻女性的数量,因为化学疗法和辐射的毒性毒性作用。儿童癌症治疗的促毒性毒性因辐射方案和所用化学治疗药物而变化。虽然美国临床肿瘤学会指南推荐所有患者的生育保存,但对儿科和青少年女性人口的生育保存有几个障碍和道德考虑。此外,Pre-undubertal女性的生育保存方法不同,仅适用于Prepubertal女性的实验方法。我们将审查化疗和辐射对女性生育的风险,儿科和青少年女性种群的生育保存方法,促使淘汰女性的生育保存方法,生育保存,成本和心理和道德考虑的障碍。 (c)2018年elestvier有限公司保留所有权利。

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