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Female fertility preservation in the pediatric and adolescent cancer patient population

机译:女性生育保存在儿科和青少年癌症患者人口中

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The 5-year survival rate for childhood cancer is over 80%, thereby increasing the number of young women facing infertility in the future because of the gonadotoxic effects of chemotherapy and radiation. The gonadotoxic effects of childhood cancer treatment vary by the radiation regimen and the chemotherapeutic drugs utilized. Although the American Society of Clinical Oncology guidelines recommend fertility preservation for all patients, there are several barriers and ethical considerations to fertility preservation in the pediatric and adolescent female population. Additionally, the fertility preservation methods for pre- and postpubertal females differ, with only experimental methods available for prepubertal females. We will review the risk of chemotherapy and radiation on female fertility, the approach to fertility preservation in the pediatric and adolescent female population, methods of fertility preservation for both pre- and postpubertal females, barriers to fertility preservation, cost, and psychological and ethical considerations. (C) 2018 Elsevier Ltd. All rights reserved.
机译:儿童癌症的5年生存率超过80%,因此,由于化疗和放疗的促性腺毒性作用,未来面临不孕症的年轻女性人数将增加。儿童癌症治疗的促性腺激素效应因放疗方案和使用的化疗药物而异。尽管美国临床肿瘤学会指南建议所有患者保留生育能力,但在儿童和青少年女性人群中保留生育能力存在一些障碍和伦理考虑。此外,青春期前和青春期后女性的生育能力保持方法有所不同,只有实验方法可用于青春期前女性。我们将回顾化疗和放疗对女性生育能力的风险,在儿童和青少年女性人群中保持生育能力的方法,青春期前和青春期后女性的生育能力保持方法,保持生育能力的障碍,成本,以及心理和伦理考虑。(C) 2018爱思唯尔有限公司版权所有。

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