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首页> 外文期刊>Canadian journal of diabetes >The Effects of Natural Clinoptilolite and Nano-Sized Clinoptilolite Supplementation on Glucose Levels and Oxidative Stress in Rats With Type 1 Diabetes
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The Effects of Natural Clinoptilolite and Nano-Sized Clinoptilolite Supplementation on Glucose Levels and Oxidative Stress in Rats With Type 1 Diabetes

机译：天然肺炎骨珠和纳米尺寸临床植物对1型糖尿病大鼠葡萄糖水平和氧化应激的影响

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ObjectiveOxidative stress has a major role in development of diabetic complications. In this study we investigated whether clinoptilolite and nano-sized clinoptilolite could reduce hyperglycemia and oxidative stress in streptozotocin-induced diabetic rats and attempted to determine which intervention was more effective. MethodsThirty-six rats were randomly allocated to 2 groups; 1 group was randomly chosen as a diabetic group and injected with streptozotocin (60?mg/kg body weight in 0.1?mol/L sodium citrate buffer, pH 4.5) to induce diabetes. Three days after diabetes induction, each group (diabetic group and nondiabetic group) was randomly divided into 3 subgroups of 6 animals each ([1] control, [2] 1% clinoptilolite/food, [3] 1% nano-sized clinoptilolite/food). Supplementation was continued for 28 days. Blood glucose was measured 3 times, at the beginning of the study and on the 14th and 28th days. Activity of antioxidant enzymes, including glutathione peroxidase and superoxide dismutase, and levels of total antioxidant capacity, as well as malondialdehyde, were evaluated. ResultsBlood glucose and malondialdehyde were significantly elevated, but there were no statistically significant changes in superoxide dismutase, glutathione peroxidase or total antioxidant capacity in diabetic rats. In diabetic rats treated with nano-sized clinoptilolite, blood glucose decreased to near normal levels (12.4 vs.27.5?mmol/L). No significant changes were found in the other groups. None of the oxidative stress indices showed significant changes in either the treated or untreated rats. ConclusionNano-sized clinoptilolite exerted a hypoglycemic effect in streptozotocin-induced diabetic rats but had no significant influence on oxidative stress markers.
机译：objectOx递减应激在糖尿病并发症的发展中具有重要作用。在这项研究中，我们调查了Clinapholegolite和纳米尺寸的Clinopholite可以降低链脲佐菌素诱导的糖尿病大鼠的高血糖和氧化应激，并试图确定哪种干预更有效。方法将六只大鼠随机分配给2组;将1组随机选择作为糖尿病组，并用链脲佐菌素（60×mg / kg体重为0.1〜摩尔/克柠檬酸钠缓冲液，pH4.5）注射以诱导糖尿病。糖尿病诱导三天后，每组（糖尿病组和非糖尿病组）随机分为3个动物的3个亚组（[1]对照，[2] 1％Clinophogolite / Fook，[3] 1％纳米尺寸的Clinopholite /食物）。补充持续28天。测量血糖3次，在研究开始，第14天和第28天。评价抗氧化酶的活性，包括谷胱甘肽过氧化物酶和超氧化物歧化酶，以及总抗氧化能力以及丙二醛的水平。结果手表葡萄糖和丙二醛明显升高，但过氧化物歧化酶，糖硫磷酸过氧化物酶或糖尿病大鼠总抗氧化能力没有统计学显着的变化。在用纳米级临床凝结石处理的糖尿病大鼠中，血糖降低到正常水平附近（12.4Vs.27.5？mmol / L）。在其他群体中没有发现重大变化。氧化性胁迫指数均未显示治疗或未治疗的大鼠的显着变化。结论anano大小的Clinoptilolite在链脲佐菌素诱导的糖尿病大鼠中发挥了降血糖作用，但对氧化应激标记没有显着影响。

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