...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >The pectin-insulin patch application prevents the onset of peripheral neuropathy-like symptoms in streptozotocin-induced diabetic rats
【24h】

The pectin-insulin patch application prevents the onset of peripheral neuropathy-like symptoms in streptozotocin-induced diabetic rats

机译：果胶 - 胰岛素贴剂施用可以防止链脲佐菌素诱导的糖尿病大鼠中周围神经病理样症状的发作

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Peripheral neuropathic condition is amongst the classical symptoms of progressed diabetes. An intensive glycemic control with insulin injections has been shown to delay the onset and the progression of this condition in diabetes. In this study, we investigated the effect of pectin-insulin patch application on peripheral neuropathic symptoms in streptozotocin-induced diabetic rats. Pectin-insulin patches (20.0, 40.8, and 82.9 mu g/kg) were daily applied thrice in streptozotocin-induced diabetic rats for 45 days. The diabetic animals sham treated with insulin-free patch served as negative control, while diabetic animals receiving subcutaneous insulin served as positive controls. The locomotor activity, gripping strength, and thermal perception were assessed at day 36, day 40, and day 44, respectively. On the 45th day, the animals were sacrificed, after which the plasma insulin, nitric oxide, C-reactive protein, tumor necrosis factor alpha, and malondialdehyde were measured. The patch application attenuated hyperglycemia with an improvement in the locomotor activity, thermal perception, and gripping strength in diabetic animals. Furthermore, the application of the patch augmented plasma nitric oxide while attenuating plasma malondialdehyde and tumor necrosis factor alpha. The application of pectin-insulin patch delays the onset of peripheral neuropathiclike symptoms in diabetic animals.
机译：外周神经病病症是进展糖尿病的经典症状。已经显示出胰岛素注射的强化血糖对照，延迟了糖尿病中这种病症的发病和进展。在这项研究中，我们研究了果胶蛋白贴剂在链脲佐菌素诱导的糖尿病大鼠中对外周神经病理症状的影响。果胶蛋白贴剂（20.0,40.8和82.9μmg/ kg）每天在链脲佐菌素诱导的糖尿病大鼠中施用45天。糖尿病患者假处理用胰岛素的贴剂处理为阴性对照，而接受皮下胰岛素的糖尿病动物用作阳性对照。在第36天，第40天和第44天评估运动活性，夹持强度和热感知。在第45天，处死动物，之后测量血浆胰岛素，一氧化氮，C反应蛋白，肿瘤坏死因子α和丙二醛。贴剂申请减弱了高血糖，随着运动活性，热感知和饲养的力量的改善而改善了糖尿病动物。此外，贴片增强等离子体一氧化氮在衰减等离子体丙二醛和肿瘤坏死因子α的同时施用。果胶 - 胰岛素贴剂在糖尿病动物中延迟外周神经疗法症状的发作。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号