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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Hemoglobin oxygen saturation targets in the neonatal intensive care unit: Is there a light at the end of the tunnel?
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Hemoglobin oxygen saturation targets in the neonatal intensive care unit: Is there a light at the end of the tunnel?

机译:血红蛋白氧饱和度在新生儿重症监护室中的目标:隧道末端有光吗?

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摘要

The optimal oxygenation target needed to prevent the extremes of hypoxia and oxygen toxicity in premature and sick newborns has been the subject of much research and debate. The advent of the pulse oximeter has allowed the continuous monitoring of oxyhemoglobin saturation and the delivery of oxygen with greater precision. Well-run, large clinical trials to determine the safest oxygen concentration have led to several revisions in guidelines for neonatal care. However, monitoring of oxyhemoglobin saturation has its limitations and does not provide a comprehensive assessment of tissue oxygenation. To identify optimal oxygen therapy, various other factors (partial pressure of arterial carbon dioxide, hemoglobin concentration, blood pH, and tissue metabolic demand) that influence perfusion and tissue oxygenation need to be considered.
机译:在早产和生病的新生儿中防止极端缺氧和氧气毒性所需的最佳氧合靶是有多大研究和辩论的主题。 脉搏血氧仪的出现允许连续监测氧气血红蛋白饱和度,并具有更高的精度递送氧气。 运行良好的临床试验,以确定最安全的氧气浓度导致新生儿护理指南的若干修订。 然而,监测氧合血红蛋白饱和度具有其限制,并且不提供对组织氧合的综合评估。 为了鉴定最佳的氧疗法,需要考虑各种其他因素(各种动脉二氧化碳的分压,血红蛋白浓度,血液pH和组织代谢需求),这些因素可能考虑影响灌注和组织氧合的灌注。

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