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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Synergistic interaction between diclofenac and pyrilamine on nociception, inflammation, and gastric damage in rats
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Synergistic interaction between diclofenac and pyrilamine on nociception, inflammation, and gastric damage in rats

机译：双氯芬酸和嘧啶对大鼠伤害，炎症和胃损伤之间的协同相互作用

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Experiments using nonsteroidal anti-inflammatory drugs (NSAIDs) alone have produced limited antinociceptive effects in animal models. For this reason, the number of studies involving the administration of NSAIDs along with an adjuvant drug harboring different mechanisms of action has increased enormously. Here, combinations of diclofenac and pyrilamine were used to determine their influence on nociception (formalin test), inflammation (paw inflammation produced by carrageenan), and gastric damage in rodents. Diclofenac, pyrilamine, or combinations of diclofenac and pyrilamine produced antinociceptive and anti-inflammatory effects in the rat. The systemic administration of diclofenac alone and in combination with pyrilamine produced significant gastric damage. Effective dose (ED) values were determined for each individual drug, and isobolograms were prepared. The theoretical ED values for the antinociceptive (systemic, 35.4 mg/kg; local, 343.4 mu g/paw) and the anti-inflammatory (37.9 mg/kg) effects differed significantly from the experimental ED values (systemic antinociception, 18.1 mg/kg; local antinociception, 183.3 mu g/paw; anti-inflammation, 10.6 mg/kg). Therefore, it was concluded that the interactions between diclofenac and pyrilamine are synergistic. The data suggest that the diclofenac-pyrilamine combinations can interact at the systemic and local peripheral levels, thereby offering a therapeutic alternative for the clinical management of inflammatory pain.
机译：单独使用非甾体抗炎药（NSAID）的实验在动物模型中产生了有限的抗伤触性。因此，涉及NSAID的研究数量以及含有不同作用机制的佐剂药物的次数大幅增加。在此，使用双氯芬酸和嘧胺的组合来确定它们对伤害（福尔马林试验），炎症（Carrageenan产生的爪子炎症）的影响，以及啮齿动物的胃损伤。双氯芬酸，嘧胺，或双氯芬酸和嘧胺的组合产生了大鼠的抗闭合体和抗炎作用。单独的双氯芬酸和与嘧啶组合的全身施用产生显着的胃损伤。针对每个单独的药物测定有效剂量（ED）值，并制备异疣。抗闭合体的理论ED值（系统性，35.4mg / kg;局部，343.4μg/爪子）和抗炎（37.9mg / kg）的效果显着不同于实验的ED值（全身性抗妇科，18.1mg / kg ;局部抗梗阻，183.3μg/爪子;抗炎，10.6mg / kg）。因此，得出结论是双氯芬酸和嘧胺之间的相互作用是协同的。该数据表明双氯芬酰基 - 嘧胺组合可以在全身和局部外周水平处相互作用，从而为炎症疼痛的临床管理提供治疗替代品。

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