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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Aspirin and (or) omega-3 polyunsaturated fatty acids protect against corticohippocampal neurodegeneration and downregulate lipoxin A(4) production and formyl peptide receptor-like 1 expression in pentylenetetrazole-kindled rats
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Aspirin and (or) omega-3 polyunsaturated fatty acids protect against corticohippocampal neurodegeneration and downregulate lipoxin A(4) production and formyl peptide receptor-like 1 expression in pentylenetetrazole-kindled rats

机译：Aspirin和（或）ω-3多不饱和脂肪酸可保护皮质流溅神经变性，下调脂氧蛋白A（4）制备和甲醛肽受体样1表达在戊烯烯烯烯丁唑.燃点大鼠中

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摘要

There is evidence for a relationship between inflammation and seizures because epilepsy can be caused by or result in inflammation. This study aimed to investigate the effect of aspirin and (or) omega-3 polyunsaturated fatty acids (PUFAs) on seizure activity and neurodegeneration in pentylenetetrazole (PTZ)-kindled rats focusing on their effect on corticohippocampal production of lipoxin A(4) (LXA(4)) and expression of formyl peptide receptor-like 1 (FPRL1) receptors. Male rats were injected with PTZ (35 mg/kg, i.p.) 3 times per week for a total of 15 doses. Rats were treated daily with aspirin (20 mg/kg, i.p.), omega-3 PUFAs (85 mg/kg, p.o.), or a combination of them for 35 days. Both LXA(4) level and expression of FPRL1 receptor in the cortices and hippocampi of rats' brains were greater in PTZ-kindled rats compared to a saline control group. Cotreatment with aspirin and (or) omega-3 PUFAs reduced convulsive behaviour; reduced levels of LXA(4), interleukin-1 beta, and nuclear factor-kappa B; and showed a lower percentage of corticohippocampal degenerative cells compared to PTZ-kindled rats. The combination of the 2 therapeutic agents did not provide significant improvement in comparison with the monotherapies. These findings suggest the use of aspirin or omega-3 PUFAs may delay the development of seizures and provide neuroprotection in a clinical setting.
机译：有证据表明炎症和癫痫发作之间的关系，因为癫痫症可能是由炎症引起的或导致炎症。本研究旨在探讨阿司匹林和（或）ω-3多不饱和脂肪酸（Pufas）对癫痫唑（PTZ）的癫痫发作活性和神经变性的影响 - 令人兴奋的大鼠对脂唑素A（4）（LXA的影响（4））和甲醛肽受体样1（FPRL1）受体的表达。将雄性大鼠每周用PTZ（35mg / kg，I.P.）注射3次，共15剂。每天用阿司匹林（20mg / kg，i.p.），ω-3 pufas（85mg / kg，p.o.）或35天的组合每天进行大鼠。与盐水对照组相比，在PTZ-Lindled大鼠中，LXA（4）水平和FPR1受体的表达和大鼠大脑的海马在较大的大鼠中更大。与阿司匹林和（或）ω-3 pufas的加曲调减少了惊厥行为;降低LXA（4），白细胞介素-1β和核因子-Kappa B的水平;与PTZ-LINGLED大鼠相比，表现出较低百分比的皮质捕食性退化细胞。与单极相比，2种治疗剂的组合没有提供显着的改善。这些发现表明Aspirin或Omega-3 pufas的使用可能会延迟癫痫发作的发育并在临床环境中提供神经保护。

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