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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Effects of cannabinoid and vanilloid receptor agonists and their interaction on learning and memory in rats
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Effects of cannabinoid and vanilloid receptor agonists and their interaction on learning and memory in rats

机译：大麻素和香草素受体激动剂的影响及其对大鼠学习记忆的影响

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摘要

Despite previous findings on the effects of cannabinoid and vanilloid systems on learning and memory, the effects of the combined stimulation of these 2 systems on learning and memory have not been studied. Therefore, in this study, we tested the interactive effects of cannabinoid and vanilloid systems on learning and memory in rats by using passive avoidance learning (PAL) tests. Forty male Wistar rats were divided into the following 4 groups: (1) control (DMSO+saline), (2) WIN55,212-2, (3) capsaicin, and (4) WIN55,212-2 +capsaicin. On test day, capsaicin, a vanilloid receptor type 1 (TRPV1) agonist, or WIN55,212-2, a cannabinoid receptor (CB1/CB2) agonist, or both substances were injected intraperitoneally. Compared to the control group, the group treated with capsaicin (TRPV1 agonist) had better scores in the PAL acquisition and retention test, whereas treatment with WIN55,212-2 (CB1/CB2 agonist) decreased the test scores. Capsaicin partly reduced the effects of WIN55,212-2 on PAL and memory. We conclude that the acute administration of a TRPV1 agonist improves the rats' cognitive performance in PAL tasks and that a vanilloid-related mechanism may underlie the agonistic effect of WIN55,212-2 on learning and memory.
机译：尽管先前关于大麻素和香草系统对学习和记忆的影响的发现，但尚未研究对学习和记忆中这两个系统的组合刺激的影响。因此，在本研究中，我们通过使用被动避免学习（PAL）测试测试了大麻素和香草系统对大鼠学习和记忆的互动效果。分为以下4组：（1）对照（DMSO +盐水），（2）Win55,212-2，（3）辣椒素，（4）Win55,212-2 + Capsaicin。在试验日，辣椒素，一种香草素受体1（TRPV1）激动剂，或Win55,212-2，大麻素受体（CB1 / CB2）激动剂或两种物质被腹膜内注射。与对照组相比，用辣椒素（TRPV1激动剂）处理的组在PAL采集和保留试验中具有更好的分数，而使用Win55,212-2（CB1 / CB2激动剂）的治疗降低了测试评分。辣椒素部分减少了Win55,212-2对PAL和记忆的影响。我们得出结论，TRPV1激动剂的急性施用改善了在PAL任务中的老鼠认知性能，并且类胡椒相关机制可能使WIN55,212-2对学习和记忆的激动效应。

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