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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Effect of vitamin D on isoprenaline-induced myocardial infarction in rats: possible role of peroxisome proliferator-activated receptor-gamma
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Effect of vitamin D on isoprenaline-induced myocardial infarction in rats: possible role of peroxisome proliferator-activated receptor-gamma

机译：维生素D对大鼠异戊酮诱导的心肌梗死的影响：过氧化物体增殖物激活受体 - γ的可能作用

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摘要

Infarct-like lesion induced by isoprenaline is a well-known model to study myocardial infarction (MI). Vitamin D has been shown to have anti-inflammatory and antioxidant effects. Recent studies highlighted cross talk between vitamin D and peroxisome proliferator-activated receptor gamma (PPAR-gamma). The present study was designed to investigate the effect of pretreatment with vitamin D on the isoprenaline-induced infarct-like lesion in rats and the role of PPAR-gamma as a novel mechanism in vitamin-D-mediated cardioprotective effect. Markers chosen to assess cardiac damage included serum level of creatine kinase (CK), lactate dehydrogenase (LDH), tumor necrosis factor-alpha (TNF-alpha), and interleukin-6 (IL-6). Cardiac contents of malondialdehyde (MDA), superoxide dismutase (SOD), and glutathione peroxidase (GSH) were also assessed. Furthermore, ECG monitoring and measurement of injury extension were carried out. Isoprenaline increased the level of cardiac enzymes, as well as inflammatory and oxidative stress biomarkers. In addition, it produced ST-segment elevation. Pretreatment with vitamin D significantly improved previous parameters. The prior treatment with bisphenol A diglycidyl ether (BADGE), a PPAR-gamma antagonist, significantly attenuated the protective effect of vitamin D. In conclusion, vitamin D can be demonstrated as a promising cardioprotective agent in MI and PPAR-gamma significantly contributes toward vitamin-D-mediated protection.
机译：异丙肾上腺素诱导的梗塞样病变是研究心肌梗塞（MI）的众所周知的模型。已显示维生素D具有抗炎和抗氧化作用。最近的研究突出了维生素D和过氧化物体增殖物激活的受体γ（PPAR-Gamma）之间的交叉谈。本研究旨在探讨预处理对维生素D对大鼠异戊二甲酸氨基诱导的梗塞样病变的影响及PPAR-GAMMA作为维生素-D介导的心脏保护作用的新机制的作用。选择评估心脏损伤的标记包括血清肌酸激酶（CK），乳酸脱氢酶（LDH），肿瘤坏死因子-α（TNF-α）和白细胞介素-6（IL-6）。还评估了丙二醛（MDA），超氧化物歧化酶（SOD）和谷胱甘肽过氧化物酶（GSH）的心脏含量。此外，进行了ECG监测和测量损伤延伸。异丙肾上腺素增加了心脏酶的水平，以及炎症和氧化应激生物标志物。此外，它产生了ST段高度。预处理维生素D显着改善了以前的参数。用双酚A二缩水甘油醚（徽章），PPAR-Gamma拮抗剂的预处理显着减弱了维生素D的保护作用。总之，维生素D可以作为MI和PPAR-Gamma的有希望的心脏保护剂显着贡献维生素-D介导的保护。

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