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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Possible involvement of ATP-sensitive potassium channels in the antidepressant-like effects of gabapentin in mouse forced swimming test
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Possible involvement of ATP-sensitive potassium channels in the antidepressant-like effects of gabapentin in mouse forced swimming test

机译：ATP敏感性钾通道在小鼠迫使游泳试验中的抗抑郁药物的抗抑郁药物的诱导效果

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Gabapentin as an anticonvulsant drug also has beneficial effects in treatment of depression. Previously, we showed that acute administration of gabapentin produced an antidepressant-like effect in the mouse forced swimming test (FST) by a mechanism that involves the inhibition of nitric oxide (NO). Considering the involvement of NO in adenosine triphosphate (ATP)-sensitive potassium channels (K-ATP), in the present study we investigated the involvement of K-ATP channels in antidepressant-like effect of gabapentin. Gabapentin at different doses (5-10 mg/kg) and fluoxetine (20 mg/kg) were administrated by intraperitoneal route, 60 and 30 min, respectively, before the test. To clarify the probable involvement of K-ATP channels, mice were pretreated with K-ATP channel inhibitor or opener. Gabapentin at dose 10 mg/kg significantly decreased the immobility behavior of mice similar to fluoxetine (20 mg/kg). Co-administration of subeffective dose (1 mg/kg) of glibenclamide (inhibitor of K-ATP channels) with gabapentin (3 mg/kg) showed a synergistic antidepressant-like effect. Also, subeffective dose of cromakalim (opener of K-ATP channels, 0.1 mg/kg) inhibited the antidepressant-like effect of gabapentin (10 mg/kg). None of the treatments had any impact on the locomotor movement. Our study, for the first time, revealed that antidepressant-like effect of gabapentin in mice is mediated by blocking the K-ATP channels.
机译：加巴彭汀作为抗惊厥药物也有益于抑郁症的效果。以前，我们表明，加巴普丁的急性施用在小鼠迫使游泳试验（FST）中产生了一种类似的机制，该机制涉及抑制一氧化氮（NO）。考虑到NO在三磷酸（ATP） - 敏感的钾通道（K-ATP）中的参与，在本研究中，我们研究了K-ATP通道在加巴亨坦植物的抗抑郁药物的抗抑郁作用中的累积。在试验前分别通过腹膜内途径，60和30分钟给予不同剂量（5-10mg / kg）和氟西汀（20mg / kg）的加布普坦丁。为了阐明K-ATP通道的可能涉及，用K-ATP通道抑制剂或开罐预处理小鼠。 10 mg / kg剂量的加布普坦素显着降低了与氟西汀类似（20mg / kg）的小鼠的不动行行为。用加巴邦（3mg / kg）的Glibenclamide（K-ATP通道的抑制剂）的亚霉素（K-ATP通道抑制剂）的共聚给药显示出协同抗抑郁剂样效果。此外，Cromakalim（K-ATP通道的开孔，0.1mg / kg）的亚溴肟（k-ATP通道的开孔）抑制了加巴普丁（10mg / kg）的抗抑郁药物。没有任何治疗对运动运动产生任何影响。我们首次研究揭示了通过阻断K-ATP通道来介导的甘地蛋白在小鼠中的抗抑郁药物的效果。

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