Advanced glycation end products affect cholesterol homeostasis by impairing ABCA1 expression on macrophages

Olivier Kamtchueng Simo; Souade Ikhlef; Hicham Berrougui; Abdelouahed Khalil

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Advanced glycation end products affect cholesterol homeostasis by impairing ABCA1 expression on macrophages

机译：先进的糖化末端产品通过在巨噬细胞上损害ABCA1表达来影响胆固醇稳态

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3 H]cholesterol levels in the plasma of D-gal-treated mice after 48 h compared with control mice, P 3 H]cholesterol levels in the plasma, although the levels were lower than those of control mice. The in vitro incubation of HDLs with dicarbonyl compounds increased the carbonyl and conjugated diene content of HDLs and significantly reduced PON1 paraoxonase activity (87.4% lower than control HDLs, P P P

机译：3 H]胆固醇水平在48小时后D-GAL处理的小鼠血浆与对照小鼠比对照小鼠，P 3 H]胆固醇水平在血浆中，尽管水平低于对照小鼠的水平。用二羰基化合物的HDLS的体外孵育增加了HDL的羰基和缀合的二烯含量，显着降低了PON1酰氧酶活性（比对照HDL低87.4％，P P P

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来源
《Canadian Journal of Physiology and Pharmacology》 |2017年第8期|共8页
作者
Olivier Kamtchueng Simo; Souade Ikhlef; Hicham Berrougui; Abdelouahed Khalil;
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作者单位

Research Centre on Aging Sherbrooke QC J1H 4C4 Canada.;

Research Centre on Aging Sherbrooke QC J1H 4C4 Canada.;

Research Centre on Aging Sherbrooke QC J1H 4C4 Canada.;

Research Centre on Aging Sherbrooke QC J1H 4C4 Canada.;

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原文格式 PDF
正文语种 eng
中图分类药理学;
关键词
advanced glycation end products; HDL; reverse cholesterol transport; aging;

机译：先进的糖化末端产品;HDL;反向胆固醇运输;老化;

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专利

1. Advanced glycation end products affect cholesterol homeostasis by impairing ABCA1 expression on macrophages [J] . Olivier Kamtchueng Simo, Souade Ikhlef, Hicham Berrougui, Canadian Journal of Physiology and Pharmacology . 2017,第8期

机译：先进的糖化末端产品通过在巨噬细胞上损害ABCA1表达来影响胆固醇稳态
2. Rosiglitazone inhibits expression of acyl-coenzyme A:cholesterol acyltransferase-1 in THP-1 macrophages induced by advanced glycation end-products [J] . Yang Qihong, Xu Qiang, Zhang Hong, 中国人民解放军军医大学学报（英文版） . 2008,第003期

机译：罗格列酮抑制晚期糖基化终产物诱导的THP-1巨噬细胞中酰基辅酶A：胆固醇酰基转移酶-1的表达
3. Atorvastatin Blocks Advanced Glycation End Products Induced Reduction in Macrophage Cholesterol Efflux Mediated With ATP-Binding Cassette Transporters G 1 [J] . Lei Xu, Yi-ru Wang, Pei-cheng Li, Circulation journal . 2019,第9期

机译：阿托伐他汀阻滞高级糖化终产物诱导的ATP结合盒式转运蛋白G 1介导的巨噬细胞胆固醇外流减少。
4. PDE Inhibitor Rolipram Increases Cholesterol Efflux and ABCA1 Expression: Rolipram Increases ABCA1 Expression [C] . He Ping-Ping, OuYang Xin-Ping, Yin Kai, Biomedical Engineering and Biotechnology (iCBEB), 2012 International Conference on . 2012

机译：PDE抑制剂Rolipram增加胆固醇流出和ABCA1表达：Rolipram增加ABCA1表达
5. Influence of Four Differently Processed Diets on Plasma Levels of Advanced Glycation End Products (Ages), Serum Levels of Receptor for Advanced Glycation End Products (Rage), Serum and Urine Metabolome, and Fecal Microbiome in Healthy Dogs [D] . ?Bridglalsingh, Siobhan 2020

机译：四种不同加工饮食对晚期糖糖末端产物（年龄），晚期糖糖末端产物（RAGE），血清和尿液代谢的血清受体水平的影响，以及健康犬的粪便微生物组
6. Advanced glycation end products increase lipids accumulation in macrophages through upregulation of receptor of advanced glycation end products: increasing uptake esterification and decreasing efflux of cholesterol [O] . Lei Xu, Yi-Ru Wang, Pei-Cheng Li, 2016

机译：晚期糖基化终产物通过上调糖基化终产物的受体的表达来增加巨噬细胞中脂质的积累：增加胆固醇的摄取酯化并降低胆固醇的外流
7. Advanced glycation end products affect cholesterol homeostasis by impairing ABCA1 expression on macrophages [O] . Olivier Kamtchueng Simo, Souade Ikhlef, Hicham Berrougui, 2017

机译：先进的糖化末端产品通过在巨噬细胞上损害ABCA1表达来影响胆固醇稳态

Advanced glycation end products affect cholesterol homeostasis by impairing ABCA1 expression on macrophages

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