A primer on current progress in cardiac fibrosis

Danah Al Hattab; Michael P. Czubryt

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A primer on current progress in cardiac fibrosis

机译：心肌纤维化目前进展的底漆

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Cardiac fibrosis is a significant global health problem that is closely associated with multiple forms of cardiovascular disease, including myocardial infarction, dilated cardiomyopathy, and diabetes. Fibrosis increases myocardial wall stiffness due to excessive extracellular matrix deposition, causing impaired systolic and diastolic function, and facilitating arrhythmogenesis. As a result, patient morbidity and mortality are often dramatically elevated compared with those with cardiovascular disease but without overt fibrosis, demonstrating that fibrosis itself is both a pathologic response to existing disease and a significant risk factor for exacerbation of the underlying condition. The lack of any specific treatment for cardiac fibrosis in patients suffering from cardiovascular disease is a critical gap in our ability to care for these individuals. Here we provide an overview of the development of cardiac fibrosis, and discuss new research directions that have recently emerged and that may lead to the creation of novel treatments for patients with cardiovascular diseases. Such treatments would, ideally, complement existing therapy by specifically focusing on amelioration of fibrosis.

机译：心肌纤维化是一个重要的全球健康问题，与多种形式的心血管疾病密切相关，包括心肌梗塞，扩张心肌病和糖尿病。由于过度的细胞外基质沉积，纤维化增加了心肌壁刚度，导致收缩系统和舒张功能受损，促进心律失常。结果，与患有心血管疾病的人相比，患者的发病率和死亡率通常会显着升高，但没有明显的纤维化，证明纤维化本身是对现有疾病的病理反应和显着的危险因素，用于加剧潜在条件的恶化。患有心血管疾病的患者缺乏任何特异性治疗心肌纤维化是我们照顾这些人的关键差距。在这里，我们提供了心肌纤维化的发展概述，并讨论了最近出现的新研究方向，可能导致对心血管疾病患者的新疗法产生新的治疗方法。理想情况下，这种治疗将通过专门关注纤维化的改善来补充现有的治疗。

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《Canadian Journal of Physiology and Pharmacology》 |2017年第10期|共9页
作者
Danah Al Hattab; Michael P. Czubryt;
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作者单位

Institute of Cardiovascular Sciences St. Boniface Hospital Albrechtsen Research Centre 351 Tache;

Institute of Cardiovascular Sciences St. Boniface Hospital Albrechtsen Research Centre 351 Tache;

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原文格式 PDF
正文语种 eng
中图分类药理学;
关键词
cardiac fibrosis; extracellular matrix; fibrosis therapy; fibroblast; myofibroblast;

机译：心肌纤维化;细胞外基质;纤维化治疗;成纤维细胞;肌纤维细胞;

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1. A primer on current progress in cardiac fibrosis [J] . Danah Al Hattab, Michael P. Czubryt Canadian Journal of Physiology and Pharmacology . 2017,第10期

机译：心肌纤维化目前进展的底漆
2. Noncoding RNA as regulators of cardiac fibrosis: current insight and the road ahead [J] . Tao Hui, Yang Jing-Jing, Hu Wei, Pfluegers Archiv: European Journal of Physiology . 2016,第6期

机译：非编码RNA作为心脏纤维化的调节剂：当前的见解和未来之路
3. Histone deacetylases in cardiac fibrosis: Current perspectives for therapy [J] . Hui Tao, Kai-Hu Shi, Jing-Jing Yang, Cellular Signalling . 2014,第3期

机译：心脏纤维化中的组蛋白脱乙酰基酶：治疗的当前观点
4. Printing Mechanically Tunable Cardiac Decellularized Extracellular Matrix Bioinks for Modeling Cardiac Fibrosis [C] . Yu Jung Shin, Ryan Shafranek, Jonathan Tsui, Society for Biomaterials annual meeting and exposition . 2019

机译：印刷机械可调的心脏脱细胞的细胞外基质生物墨水，用于建模心脏纤维化
5. GRK5 Is a Novel Regulator of Fibroblast Activation and Cardiac Fibrosis [D] . Eguchi, Akito. 2022

机译：GRK5是一种新型的成纤维细胞活化和心肌纤维化调节剂
6. Examining the relationship between cardiac troponin T and cardiac morphology function and fibrosis - a cardiac magnetic resonance study [O] . Mohamad G Ghosn, Stephen Pickett, Patrick W Green, 2015

机译：检查心脏肌钙蛋白T与心脏形态功能和纤维化之间的关系-心脏磁共振研究
7. MODERATED EPOSTERS1385Longitudinal strain assessment in dilated cardiomyopathy patients using a novel accelerated DENSE sequence1407Simultaneous T1 and T2 cardiac quantification with CABIRIA: initial clinical experience1423Head-to-head comparison of acceleration algorithms in 4-dimensional flow CMR1502Left ventricular function and size evaluated by hybrid cardiac positron emission tomography-magnetic resonance: Intraindividual comparison of left ventricular ejection fraction and ventricular volumes derived by two modalities1510Left Atrium assessed by Cardiovascular Magnetic Resonance at 1.5 and 3 Tesla – age and gender effects1514Comparison of Free Breathing Cardiac MRI Radial technique to the Standard Multi breath-hold cine SSFP CMR technique for the assessment of LV Volumes and Function1536Self-navigated free-breathing isotropic 3D whole heart phase sensitive inversion recovery magnetic resonance without navigator for detection of myocardial infarction1547Assessment of Right Ventricular Strain Using Myocardial Deformation Recovery Semi Automated Technique: Initial Experience and Normal Values1586Tissue tracking myocardial deformation analysis and prediction of left ventricular remodeling in acute myocardial infarction1589Investigating strategies for optimal 31P MRS clinical cardiac at 3T: Initial Results1620Quantitative Criteria for the Diagnosis of the Congenital Absence of Pericardium by Cardiac Magnetic Resonance1632Widespread tissue injury during acute myocardial infarction: evidence from advanced CMR relaxometry1322Computed tomography coronary angiography verSus sTRess cArdiac magneTic rEsonance for the manaGement of sYmptomatic revascularized patients: a cost effectiveness study (STRATEGY study)1339Comparison of low- versus high-dose of gadobutrol for late gadolinium enhancement imaging at 1.5 Tesla: a clinical feasibility study1347Multi-parametric Cardiac Magnetic Resonance for Prediction of Cardiac Complications in Thalassemia Intermedia: a Prospective Multicenter Study1461Prognostic value of Cardiovascular Magnetic Resonance derived indexes of myocardial fibrosis in heart transplant recipients1523The role of CMR in the acute phase of hospitalization: changing paradigms1542Preoperative CMR-based score predict ventricular response after surgical left ventricular reconstruction in ischemic heart failure patients1555Excellent response rate to cardiac resynchronization therapy guided with magnetic resonance imaging1626The ECG as a predictor of arrhythmogenic substrate on Cardiac Magnetic Resonance Imaging in patients undergoing ablation for premature ventricular contractions1649Comparison of T1-mapping at 3.0T CMR and angiographic APPROACH score for area at risk assessment in ST-segment elevation myocardial infarction1340Pathological correlates of left bundle branch disease in patients with non-ischemic cardiomyopathy: a cardiovascular magnetic resonance study1342Myocardial remodelling and fibrosis in nonischaemic dilated cardiomyopathy: insights from cardiovascular magnetic resonance1411The association between fibrosis and contractile dysfunction in hypertrophic cardiomyopathy assessed by cardiovascular magnetic resonance1622Persistent myocardial inflammation due to intramyocardial haemorrhage in reperfused STEMI as a precursor to adverse LV remodelling - insights from multi-parametric mapping1566Semiquantitative analysis of low and high b value DWI for detecting myocardial edema in acute myocarditis1567Value of Cardiac MRI In Detecting Coronary Artery Disease In Newly Diagnosed Systolic Dysfunction1570Usefulness of cardiac magnetic resonance in tuberous sclerosis complex1578Papillary muscles offer further insight into hypertrophied hearts: a cardiovascular magnetic resonance study1627Diagnostic and clinical implications of CMR timing (early versus late) in patients with troponin positive acute coronary syndromes and unobstructed coronary arteries: Table 1. [O] . Upasana Tayal, Alexandros Kallifatidis, P. Garg, 2016

机译：在使用新的扩张型心肌病的患者缓和EPOSTERS1385Longitudinal应变评估加速DENSE sequence1407Simultaneous T1和T2与CABIRIA心脏定量：在4维流动的加速算法初始临床experience1423Head对头比较CMR1502Left心室功能和尺寸由混合心脏正电子发射断层摄影术评价 - 磁性共振：由两个modalities1510Left庭派生左室射血分数和心室体积的个体间的比较，在1.5和3特斯拉评估心血管磁共振 - 免费的年龄和性别effects1514Comparison呼吸心脏MRI径向技术标准的多屏气电影SSFP CMR技术的LV卷和Function1536Self-导航自由呼吸各向同性3D整个心脏相位敏感反转恢复磁共振导航仪没有检测右Ventricu心肌infarction1547Assessment的评估拉尔菌株使用心肌变形恢复半自动技术：初步经验和正常Values1586Tissue跟踪心肌变形分析和预测左室重构急性心肌infarction1589Investigating策略优化31P MRS临床心脏在3T：初始Results1620Quantitative标准的先天缺失的诊断心包心脏磁Resonance1632Widespread组织损伤急性心肌梗死时：证据先进CMR relaxometry1322Computed CT冠状动脉成像与压力心脏磁共振对症的管理吻合血管患者：成本效益研究（战略研究）1339Comparison低与高剂量钆布醇在1.5特斯拉晚钆增强成像的临床可行性，在中间型地贫心脏并发症的预测study1347Multi参数心脏核磁共振的前瞻性德穆尔心血管磁共振的ticenter Study1461Prognostic价值衍生心肌纤维化指标在住院的急性期CMR的心脏移植recipients1523The作用：改变基于CMR-paradigms1542Preoperative比分预测缺血性心脏衰竭patients1555Excellent响应速度外科左心室重建心脏再同步化后心室反应治疗与磁共振imaging1626The ECG导引作为心脏磁共振成像致心律失常性基板的在ST段抬高心肌infarction1340Pathological在风险评估经历在3.0T CMR T1映射的室性早搏contractions1649Comparison和血管造影APPROACH分数区域消融患者的预测左束支传导疾病的患者与非缺血性心肌病相关因素：心血管磁共振study1342Myocardial重塑和纤维化nonischaemic扩张型心肌病：在从在由心血管磁性resonance1622Persistent心肌炎症评估肥厚型心肌病的纤维化和收缩功能障碍之间心血管磁性resonance1411The协会由于心肌内出血景点在再灌注STEMI为先导，以不利的LV重塑 - 从低的多参数mapping1566Semiquantitative分析和高的b值DWI的见解为在心脏MRI检测冠状动脉疾病急性myocarditis1567Value在结节性硬化症complex1578Papillary肌肉初诊收缩期Dysfunction1570Usefulness心脏磁共振检测心肌水肿提供进一步的深入了解肥大心脏：心血管磁共振study1627Diagnostic和CMR定时的临床意义（早期与晚）患者肌钙蛋白阳性的急性冠脉综合征和通畅的冠状动脉：表1。

A primer on current progress in cardiac fibrosis

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