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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Geraniol promotes functional recovery and attenuates neuropathic pain in rats with spinal cord injury
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Geraniol promotes functional recovery and attenuates neuropathic pain in rats with spinal cord injury

机译：大竺葵促进功能恢复，并抑制脊髓损伤大鼠的神经性疼痛

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摘要

Geraniol, a plant-derived monoterpene, has been extensively studied and showed a wide variety of beneficial effects. The aim of this study was to investigate the therapeutic effect of geraniol on functional recovery and neuropathic pain in rats with spinal cord injury (SCI). Rats received a clip-compression SCI and were treated with geraniol 6 h following SCI. Treatment of SCI rats with geraniol markedly improved locomotor function, and reduced sensitivity to the mechanical allodynia and thermal hyperalgesia. Treatment of SCI rats with geraniol increased NeuN-positive cells, suppressed expression of glial fibrillary acidic protein, and reduced activity of caspase-3 in the injured region. Treatment of SCI rats with geraniol reduced levels of malondialdehyde and 3-nitrotyrosine, upregulated protein expression of nuclear factor-erythroid 2-related factor 2 and heme oxygenase 1, and suppressed expression of inducible nitric oxide synthase in the injured region. In addition, treatment of SCI rats with geraniol downregulated protein expression of N -methyl-d-aspartate receptor 1 and reduced the number of CD68-positive cells and protein levels of TNF-α in the injured region. In conclusion, geraniol significantly promoted the recovery of neuronal function and attenuated neuropathic pain after SCI.
机译：Geraniol是一种植物衍生的单醇萜烯，已被广泛研究并显示出各种各样的有益效果。本研究的目的是探讨小兰醇对脊髓损伤（SCI）大鼠功能性回收和神经性疼痛的治疗作用。大鼠接受夹子压缩SCI，并用Geraniol 6h接受SCI处理。用大苯胺治疗SCI大鼠显着改善的运动功能，降低了对机械异常性病和热痛觉的敏感性。含有大竺葵的SCI大鼠的治疗增加了Neun阳性细胞，抑制了粘性纤维酸性酸性蛋白的表达，并减少了受伤区域Caspase-3的活性。用丙二醇降低丙二醇和3-硝基霉素，核因子 - 红细胞2相关因子2和血红素氧合酶1的上调蛋白表达的SCI大鼠，抑制损伤区域中诱导型一氧化氮合酶的表达。此外，用大竺葵的蛋白质蛋白表达对N-甲基-D-天冬氨酸受体1的蛋白表达进行治疗，并降低了受伤区域中TNF-α的CD68阳性细胞和蛋白质水平的数量。总之，小苯胺显着促进了神经元功能的恢复并在SCI后减弱神经性疼痛。

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