• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Female offspring born to obese and insulin-resistant dams are not at increased risk for obesity and metabolic dysfunction during early development
【24h】

Female offspring born to obese and insulin-resistant dams are not at increased risk for obesity and metabolic dysfunction during early development

机译：出生于肥胖和胰岛素抗性水坝的女性后代并非在早期发展期间的肥胖和代谢功能障碍的风险增加

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The percentage of women who are obese at the time of conception or during pregnancy is increasing, with animal and human studies demonstrating that offspring born to obese dams or mothers are at increased risk for obesity and the metabolic syndrome. Our goal was to confirm in an experimental model of metabolic syndrome in the dam, whether the offspring would be at increased risk of obesity. Conversely, we observed that male offspring born to dams with metabolic syndrome had no alterations in their body mass profiles, whereas female offspring born to dams with metabolic syndrome were heavier at weaning, but exhibited no perturbations in energy metabolism. Moreover, they gained weight at a reduced rate versus female offspring born to healthy dams, and thus weighed less at study completion. Hence, our findings suggest that factors other than increased adiposity and insulin resistance during pregnancy are responsible for the increased risk of obesity in children born to obese mothers.
机译：在概念或怀孕期间遭受肥胖的妇女的百分比正在增加，动物和人类研究表明，出生于肥胖的水坝或母亲的后代是肥胖症和代谢综合征的风险增加。 我们的目标是在大坝中代谢综合征的实验模型中确认，后代是否会增加肥胖的风险。 相反，我们观察到患有代谢综合征的坝出生的男性后代在体积剖面上没有改变，而在断奶中出生于代谢综合征的坝上的女性后代在能量代谢中没有扰动。 此外，它们以减少的速率与健康水坝出生的速率降低，因此在研究完成时较少。 因此，我们的研究结果表明怀孕期间增加了肥胖和胰岛素抵抗力的因素是对肥胖母亲出生的儿童的肥胖风险增加的原因。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号