Established and suggested exposures on CLL/SLL etiology: Results from the CLL-MCC-Spain study

Benavente Yolanda; Casabonne Delphine; Costas Laura; Robles Claudia; Alonso Esther; de la Banda Esmeralda; Gonzalez-Barca Eva; Marcos-Gragera Rafael; Llorca Javier; Tardon Adonina; Monleon Jose J.; Aymerich Marta; Campo Elias; Gimeno-Vazquez Eva; Castano-Vinyals Gemma; Aragones Nuria; Pollan Marina; Kogevinas Manolis; de Sanjose Silvia

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Established and suggested exposures on CLL/SLL etiology: Results from the CLL-MCC-Spain study

机译：CLL / SLL病因的建立和建议曝光：CLL-MCC-SPAIN研究结果

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Introduction: Chronic Lymphocytic Leukemia (CLL/SLL) is the most common adult leukemia in Western countries. Although it is mostly an indolent disease it is still incurable and with limited knowledge in relation to its etiology. We aim to confirm and quantify established risk factors for CLL/SLL using a multi-center epidemiological population-based case-control study on CLL/SLL as well as to explore new exposures inconclusively associated with CLL/SLL

机译：简介：慢性淋巴细胞白血病（CLL / SLL）是西方国家最常见的成人白血病。虽然它主要是惰性疾病，但它仍然是可抵抗的，并且与其病因有限。我们的目标是使用CLL / SLL的基于多中心流行病学人口的案例控制研究确认和量化CLL / SLL的既定风险因素，也可以探索与CLL / SLL相关联的新曝光

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来源
《Cancer epidemiology》 |2018年第2018期|共6页
作者
Benavente Yolanda; Casabonne Delphine; Costas Laura; Robles Claudia; Alonso Esther; de la Banda Esmeralda; Gonzalez-Barca Eva; Marcos-Gragera Rafael; Llorca Javier; Tardon Adonina; Monleon Jose J.; Aymerich Marta; Campo Elias; Gimeno-Vazquez Eva; Castano-Vinyals Gemma; Aragones Nuria; Pollan Marina; Kogevinas Manolis; de Sanjose Silvia;
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作者单位

Inst Catala Oncol IDIBELL Canc Epidemiol Res Programme Unit Infect &

Canc UNIC Av Gran Via 199;

Inst Catala Oncol IDIBELL Canc Epidemiol Res Programme Unit Infect &

Canc UNIC Av Gran Via 199;

Inst Catala Oncol IDIBELL Canc Epidemiol Res Programme Unit Infect &

Canc UNIC Av Gran Via 199;

Int Agcy Res Canc Sect Early Detect &

Prevent Prevent &

Implementat Grp Lyon France;

Hosp Univ Bellvitge Pathol Dept Hematol Lab Barcelona 08908 Spain;

Hosp Univ Bellvitge Pathol Dept Hematol Lab Barcelona 08908 Spain;

Inst Catala Oncol Hematol IDIBELL Barcelona 08908 Spain;

Girona Biomed Res Inst IdiBGi Catalan Inst Oncol Dept Hlth Autonomous Govt Catalonia Epidemiol;

CIBER Epidemiol &

Salud Publ CIBERESP Madrid 28029 Spain;

CIBER Epidemiol &

Salud Publ CIBERESP Madrid 28029 Spain;

CIBER Epidemiol &

Salud Publ CIBERESP Madrid 28029 Spain;

Univ Barcelona Inst Biomed Res August Pi i Sunyer IDIBAPS Hosp Clin Hematopathol Unit Pathol;

Univ Barcelona Inst Biomed Res August Pi i Sunyer IDIBAPS Hosp Clin Hematopathol Unit Pathol;

Hosp del Mar Dept Clin Hematol Barcelona 08003 Spain;

CIBER Epidemiol &

Salud Publ CIBERESP Madrid 28029 Spain;

CIBER Epidemiol &

Salud Publ CIBERESP Madrid 28029 Spain;

CIBER Epidemiol &

Salud Publ CIBERESP Madrid 28029 Spain;

CIBER Epidemiol &

Salud Publ CIBERESP Madrid 28029 Spain;

Inst Catala Oncol IDIBELL Canc Epidemiol Res Programme Unit Infect &

Canc UNIC Av Gran Via 199;

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原文格式 PDF
正文语种 eng
中图分类肿瘤学;
关键词
Etiology; Chronic lymphocytic leukemia; Waist-to-hip ratio; Case-control; Lymphoproliferative disorders; Agriculture;

机译：病因;慢性淋巴细胞白血病;腰部到髋关节比例;案例控制;淋巴抑制剂;农业;

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专利

1. Established and suggested exposures on CLL/SLL etiology: Results from the CLL-MCC-Spain study [J] . Benavente Yolanda, Casabonne Delphine, Costas Laura, Cancer epidemiology . 2018,第期

机译：CLL / SLL病因的建立和建议曝光：CLL-MCC-SPAIN研究结果
2. Final 5-year updated results from a phase 3 study (HELIOS) of ibrutinib plus bendamustine and rituximab (BR) in patients with relapsed/refractory chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL) [J] . Fraser Graeme, Chanan-Khan Asher, Demirkan Faith, Leukemia and lymphoma . 2020,第S1期

机译：最终5年的更新结果来自Ibrutinib Plus Bendamustine和Rituximab（Br）的第3阶段研究（Helios），患有复发/难治性慢性淋巴细胞白血病（CLL）/小淋巴细胞淋巴瘤（SLL）
3. Long-term efficacy and safety of first-line ibrutinib treatment for patients with CLL/SLL: 5 years of follow-up from the phase 3 RESONATE-2 study [J] . Jan A. Burger, Paul M. Barr, Tadeusz Robak, Leukemia . 2020,第3期

机译：CLL / SLL患者的一线Ibrutinib治疗的长期疗效和安全性：从第3期的5年后续转发-2研究
4. SESSION INTRODUCTION: CHARACTERIZING THE IMPORTANCE OF ENVIRONMENTAL EXPOSURES, INTERACTIONS BETWEEN THE ENVIRONMENT AND GENETIC ARCHTECTURE, AND GENETC INTERACTIONS: NEW METHODS FOR UNDERSTANDING THE ETIOLOGY OF COMPLEX TRAITS AND DISEASE [C] . MOLLY A.HALL, SHEFALI SETIA VERMA, DENNIS P.WALL, Pacific Symposium on Biocomputing . 2015

机译：会议介绍：表征环境暴露的重要性，环境与遗传考验之间的相互作用，以及GENETC相互作用：了解复杂性状和疾病的病因的新方法
5. SMZL Phenotype Etiology Most Closely Resembles a Memory B-Cell and Parallels CLL in Key Aspects [D] . Stevenson, Nikolaus T. 2019

机译：SMZL表型病因最近最似乎在关键方面的记忆B细胞和Parallels CLL
6. Extended follow-up and impact of high-risk prognostic factors from the phase 3 RESONATE study in patients with previously treated CLL/SLL [O] . J R Brown, P Hillmen, S O’Brien, -1

机译：RESONATE 3期研究对先前接受过CLL / SLL治疗的患者的后续随访和高危预后因素的影响
7. Faculty Opinions recommendation of Long-term efficacy and safety of first-line ibrutinib treatment for patients with CLL/SLL: 5 years of follow-up from the phase 3 RESONATE-2 study. [O] . Varsha Gandhi, Prithviraj Bose 2021

机译：教师意见建议，对CLL / SLL患者的一线Ibrutinib治疗的长期疗效和安全性：从第3期的5年后续进行共振-2研究。

Established and suggested exposures on CLL/SLL etiology: Results from the CLL-MCC-Spain study

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