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首页> 外文期刊>Acta oncologica. >A gel tumour phantom for assessment of the accuracy of manual and automatic delineation of gross tumour volume from FDG-PET/CT
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A gel tumour phantom for assessment of the accuracy of manual and automatic delineation of gross tumour volume from FDG-PET/CT

机译：一种凝胶肿瘤模型，用于评估从FDG-PET / CT手动和自动描绘肿瘤总体积的准确性

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Introduction. Our primary aim was to make a phantom for PET that could mimic a highly irregular tumour and provide true tumour contours. The secondary aim was to use the phantom to assess the accuracy of different methods for delineation of tumour volume from the PET images. Material and methods. An empty mould was produced on the basis of a contrast enhanced computed tomography (CT) study of a patient with a squamous cell carcinoma in the head and neck region. The mould was filled with a homogeneous fast-settling gel that contained both 18F for positron emission tomography (PET) and an iodine contrast agent. This phantom (mould and gel) was scanned on a PET/CT scanner. A series of reference tumour contours were obtained from the CT images in the PET/CT. Tumour delineation based on the PET images was achieved manually, by isoSUV thresholding, and by a recently developed three-dimensional (3D) Difference of Gaussians algorithm (DoG). Average distances between the PET-derived and reference contours were assessed by a 3D distance transform. Results. The manual, thresholding and DoG delineation methods resulted in volumes that were 146%, 86% and 100% of the reference volume, respectively, and average distance deviations from the reference surface were 1.57 mm, 1.48 mm and 1.0, mm, respectively. Discussion. Manual drawing as well as isoSUV determination of tumour contours in geometrically irregular tumours may be unreliable. The DoG method may contribute to more correct delineation of the tumour. Although the present phantom had a homogeneous distribution of activity, it may also provide useful knowledge in the case of inhomogeneous activity distributions. Conclusion. The geometric irregular tumour phantom with its inherent reference contours was an important tool for testing of different delineation methods and for teaching delineation.
机译：介绍。我们的主要目的是为PET制作幻影，该幻影可以模仿高度不规则的肿瘤并提供真实的肿瘤轮廓。第二个目的是使用模型来评估从PET图像描绘肿瘤体积的不同方法的准确性。材料与方法。在对头颈部区域鳞状细胞癌患者进行对比增强计算机断层扫描（CT）研究的基础上，制作了一个空模具。用均匀的快速沉降凝胶填充模具，该凝胶同时包含用于正电子发射断层扫描（PET）的18F和碘造影剂。在PET / CT扫描仪上扫描该模型（模具和凝胶）。从PET / CT中的CT图像获得了一系列参考肿瘤轮廓。基于PET图像的肿瘤描述是通过isoSUV阈值法和最近开发的高斯算法的三维（3D）差异（DoG）实现的。 PET轮廓线和参考轮廓线之间的平均距离通过3D距离转换进行评估。结果。手动，阈值和DoG描绘方法得出的体积分别为参考体积的146％，86％和100％，与参考表面的平均距离偏差分别为1.57 mm，1.48 mm和1.0 mm。讨论。手工绘制以及isoSUV确定几何不规则肿瘤中肿瘤轮廓的方法可能不可靠。 DoG方法可能有助于更正确地描述肿瘤。尽管当前的体模具有均匀的活动分布，但在不均匀的活动分布情况下，它也可能提供有用的知识。结论。具有固有参考轮廓的几何不规则肿瘤模型是测试不同描绘方法和教授描绘的重要工具。

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