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首页> 外文期刊>Acta oncologica. >Tumor size does not predict pathological complete response rates after pre-operative chemoradiotherapy for non-small cell lung cancer
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Tumor size does not predict pathological complete response rates after pre-operative chemoradiotherapy for non-small cell lung cancer

机译：肿瘤大小不能预测非小细胞肺癌术前放化疗后的病理完全缓解率

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摘要

Patients with locally advanced (LA) non-small cell lung carcinoma (NSCLC) and a large primary tumor are at risk of being considered to have incurable disease or excluded from radical-intent treatment [1,2]. We generally consider radical chemoradiotherapy in eligible patients so long as the risk of toxicity appears acceptable — absolute tumor size is not used to allocate treatment. We decided to test the hypothesis that even large tumors can respond well to chemoradiotherapy. We studied superior sulcus tumors (SST), considered a subgroup of NSCLC, because patients with operable SST receive induction chemoradiotherapy followed by resection. This allowed us to use pathological complete response (pCR), which has been correlated with survival, as an objective, clinically meaningful end-point of treatment response [3-6]. At the same time we also tested the hypothesis that large tumors could be sterilized with modest doses of radiotherapy (45-50 Gy).
机译：患有局部晚期（LA）非小细胞肺癌（NSCLC）和大原发肿瘤的患者有被认为患有无法治愈的疾病或被排除在根治性治疗之外的风险[1,2]。只要毒性风险似乎可以接受，我们通常考虑对符合条件的患者进行彻底放化疗，因为绝对肿瘤的大小不用于分配治疗方案。我们决定检验假说，即使是大肿瘤也能对放化疗产生良好的反应。我们研究了被认为是NSCLC的亚组的上沟肿瘤（SST），因为可手术治疗的SST患者接受诱导放化疗，然后切除。这使我们能够使用与生存率相关的病理完全缓解（pCR）作为客观，临床上有意义的治疗缓解终点[3-6]。同时，我们还检验了以下假设：可以通过适度的放疗（45-50 Gy）对大肿瘤进行灭菌。

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