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Developmental changes in ciliary motility on choroid plexus epithelial cells during the perinatal period

机译：围产期脉络丛上皮细胞睫状运动的发育变化

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摘要

Cilia have crucial roles in various developmental and physiological events. Previously, we reported that choroid plexus epithelial cells (CPECs) have multiple, nonmotile 9+0 cilia, but the cilia exhibit transient motility with variable axonemal arrangements in the neonatal period. These features make these cilia unique, as they do not fit in to the traditional categories of primary or motile cilia, and their physiological roles remain elusive. To address this issue, we studied ciliary motility on CPECs through development, with particular interest in the embryonic period. In the fetal choroid plexus of the lateral ventricles, the proportion of cells with motile cilia and their beat frequency increased over time. The ciliary motility profiles peaked near the day of birth, and gradually declined in the two weeks thereafter. The dynamic changes in ciliary motility correlated with changes in Dnahc11 expression. We demonstrated previously that the ciliary motility at P2 was insufficient to produce detectable fluid flow; thus it appears that CPEC cilia do not produce fluid flow at any point during development. Together, our results suggest that a temporally regulated, unique function of CPEC cilia may exist during the perinatal period.
机译：纤毛在各种发育和生理事件中起关键作用。以前，我们曾报道脉络丛上皮细胞（CPEC）具有多个非运动性9 + 0纤毛，但在新生儿期，纤毛表现出短暂的运动性，且轴突排列不定。这些特征使这些纤毛具有独特性，因为它们不适合传统的原发性或活动性纤毛，并且其生理作用仍然难以捉摸。为了解决这个问题，我们通过发育研究了CPEC的睫状运动，特别是在胚胎期。在侧脑室的胎儿脉络膜丛中，具有活动性纤毛的细胞比例及其搏动频率随时间增加。睫状运动特征在出生当天左右达到峰值，并在此后的两周内逐渐下降。睫状运动的动态变化与Dnahc11表达的变化相关。先前我们证明了P2处的睫状运动能力不足以产生可检测的流体流动。因此，在发育过程中，CPEC纤毛似乎在任何时候都不会产生流体流动。总之，我们的结果表明，在围产期，CPEC纤毛可能存在时间调控的独特功能。

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