The multiplicity of human formins: Expression patterns in cells and tissues

KrainerE.C.; OuderkirkJ.L.; MillerE.W.; MillerM.R.; MersichA.T.; BlystoneS.D.

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The multiplicity of human formins: Expression patterns in cells and tissues

机译：人类福尔马林的多样性：细胞和组织中的表达模式

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Formins are actin-binding proteins conserved across species from plants to humans. The formin family is defined by their common formin homology (FH2) domains. The 15 distinct human formins are involved in a broad range of cellular functions, including cell adhesion, cytokinesis, cell polarity, and cell morphogenesis. Their commonality is actin polymerization activity inherent to FH2 domains. Although still requiring much study, biochemical activity of formins has been carefully described. In contrast, much less is known of their activities in complex living systems. With the diversity of the formin family and the actin structures that they affect, an extensive future of study beckons. In this study, we report the expression level of all 15 formins in 22 different human cell and tissue types using quantitative real-time PCR. Identification of major themes in formin expression and documentation of expression profiles should facilitate the cellular study of formins.

机译：Formins是肌动蛋白结合蛋白，从植物到人类在整个物种中都是保守的。甲醛家族由其共同的甲醛同源性（FH2）结构域定义。 15种不同的人类福明蛋白涉及广泛的细胞功能，包括细胞粘附，胞质分裂，细胞极性和细胞形态发生。它们的共性是FH2结构域固有的肌动蛋白聚合活性。尽管仍需要大量研究，但已经详细描述了福尔马林的生物化学活性。相比之下，人们对它们在复杂的生活系统中的活动了解得很少。随着FORMIN家族的多样性以及它们影响的肌动蛋白结构，研究的广阔前景开始了。在这项研究中，我们使用定量实时PCR报告了22种不同的人类细胞和组织中所有15种福蛋白的表达水平。鉴定形式表达的主要主题和表达谱的文件记录应有助于福尔马林的细胞研究。

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《Cytoskeleton》 |2013年第8期|共15页
作者
KrainerE.C.; OuderkirkJ.L.; MillerE.W.; MillerM.R.; MersichA.T.; BlystoneS.D.;
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正文语种 eng
中图分类细胞生物学;
关键词
Actin; tissues; PCR; expression; Formins;

机译：肌动蛋白;组织;PCR;表达;Formins;

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1. The multiplicity of human formins: Expression patterns in cells and tissues [J] . KrainerE.C., OuderkirkJ.L., MillerE.W., Cytoskeleton . 2013,第8期

机译：人类福尔马林的多样性：细胞和组织中的表达模式
2. Tissue factor expression pattern in human non-small cell lung cancer tissues indicate increased blood thrombogenicity and tumor metastasis. [J] . Goldin-Lang P, Tran QV, Fichtner I, Oncology reports . 2008,第1期

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3. Tissue and Cellular Expression Patterns of Porcine CFTR: Similarities to and Differences From Human CFTR [J] . Stephanie Plog, Lars Mundhenk, Melanie K. Bothe, The journal of histochemistry and cytochemistry . 2010,第9期

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6. The multiplicity of human formins: Expression patterns in cells and tissues [O] . Elisabeth C. Krainer, Jessica L. Ouderkirk, Eric W. Miller, -1

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The multiplicity of human formins: Expression patterns in cells and tissues

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