Glycosylation in the Era of Cancer-Targeted Therapy: Where Are We Heading?

Mereiter Stefan; Balmana Meritxell; Campos Diana; Gomes Joana; Reis Celso A.

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Glycosylation in the Era of Cancer-Targeted Therapy: Where Are We Heading?

机译：癌症靶向治疗时代的糖基化：我们在哪里前往？

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This review provides insights on the impact of glycosylation in cancer biology and its influence in the current approaches of targeted cancer therapies in the clinical setting. The roles of glycosylation in cancer signaling, tumor progression, and metastasis are reviewed as well as glycans and glycan-binding proteins in tumor immunomodulation. Moreover, the latest reports on glycans influencing targeted therapeutic approaches in cancer are summarized. Finally, we discuss the future challenges of the field, outlining potential applications of glycan-based biomarkers for patient stratification and strategies for improving personalized cancer treatment.

机译：该审查提供了关于糖基化对癌症生物学的影响及其在临床环境中靶向癌症疗法目前方法的影响的见解。在肿瘤免疫调节中审查了糖基化在癌症信号，肿瘤进展和转移中的糖基化，肿瘤进展和转移的作用。此外，总结了影响癌症患者有针对性治疗方法的聚糖的最新报告。最后，我们讨论了该领域的未来挑战，概述了甘草基生物标志物的潜在应用，以患者分层和改善个性化癌症治疗的策略。

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《Cancer Cell》 |2019年第1期|共11页
作者
Mereiter Stefan; Balmana Meritxell; Campos Diana; Gomes Joana; Reis Celso A.;
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作者单位

Univ Porto I3S P-4200135 Porto Portugal;

Univ Porto I3S P-4200135 Porto Portugal;

Univ Porto I3S P-4200135 Porto Portugal;

Univ Porto I3S P-4200135 Porto Portugal;

Univ Porto I3S P-4200135 Porto Portugal;

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正文语种 eng
中图分类肿瘤学;
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1. Glycosylation in the Era of Cancer-Targeted Therapy: Where Are We Heading? [J] . Mereiter Stefan, Balmana Meritxell, Campos Diana, Cancer Cell . 2019,第1期

机译：癌症靶向治疗时代的糖基化：我们在哪里前往？
2. Self-Assembly of Therapeutic Peptide into Stimuli-Responsive Clustered Nanohybrids for Cancer-Targeted Therapy [J] . He Wangxiao, Wang Simeng, Yan Jin, Advanced Functional Materials . 2019,第10期

机译：治疗性肽自组装成刺激响应的簇状纳米杂交体，用于癌症靶向治疗。
3. FDPP–HA as a theranostic agent for cancer-targeted fluorescence imaging and photodynamic therapy [J] . Pingping Liang, Jinjun Shao, Qianyun Tang, RSC Advances . 2017,第59期

机译：FDPP–HA作为治疗癌症的荧光成像和光动力疗法的治疗药物
4. An Oligopeptide Ligand-Mediated Therapeutic Gene Nanocomplex for Liver Cancer-Targeted Therapy [C] . M. Liu, Z.H. Li, F.J. Xu, World biomaterials congress . 2012

机译：寡肽配体介导的肝癌靶向治疗基因纳米复合物
5. Synthesis of conjugates of L-fucose and ortho-carborane as potential agents for boron neutron capture therapy, and, Synthesis of 2,3-dideoxy-2,3-methanoribofuranoside glycosyl donors and a study of their use in stereocontrolled glycosylation reactions. [D] . Basak, Prakriti. 2003

机译：合成L-岩藻糖和邻位碳硼烷作为硼中子俘获治疗的潜在药物，以及2,3-二脱氧-2,3-甲基呋喃呋喃糖苷糖基供体的合成及其在立体控制糖基化反应中的应用研究。
6. Visualization of gene therapy with a liver cancer-targeted adeno-associated virus 3 vector [O] . Xusheng Liu, Hanling Huang, Yan Gao, 2020

机译：肝癌靶向腺相关病毒3载体基因治疗的可视化
7. FDPP–HA as a theranostic agent for cancer-targeted fluorescence imaging and photodynamic therapy [O] . Pingping Liang, Jinjun Shao, Qianyun Tang, 2017

机译：FDPP-HA作为癌症靶向荧光成像和光动力治疗的治疗剂

Glycosylation in the Era of Cancer-Targeted Therapy: Where Are We Heading?

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