The Link between the Multiverse of Immune Microenvironments in Metastases and the Survival of Colorectal Cancer Patients

Van den Eynde Marc; Mlecnik Bernhard; Bindea Gabriela; Fredriksen Tessa; Church Sarah E.; Lafontaine Lucie; Haicheur Nacilla; Marliot Florence; Angelova Mihaela; Vasaturo Angela; Bruni Daniela; Jouret-Mourin Anne; Baldin Pamela; Huyghe Nicolas; Haustermans Karin; Debucquoy Annelies; Van Cutsem Eric; Gigot Jean-Francois; Hubert Catherine; Kartheuser Alex; Remue Christophe; Leonard Daniel; Valge-Archer Viia; Pages Franck; Machiels Jean-Pascal; Galon Jerome

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The Link between the Multiverse of Immune Microenvironments in Metastases and the Survival of Colorectal Cancer Patients

机译：转移中的免疫微环境多层与结直肠癌患者的存活之间的联系

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Treatment of metastatic colorectal cancer is based upon the assumption that metastases are homogeneous within a patient. We quantified immune cell types of 603 whole-slide metastases and primary colorectal tumors from 222 patients. Primary lesions, and synchronous and metachronous metastases, had a heterogeneous immune infiltrate and mutational diversity. Small metastases had frequently a low Immunoscore and T and B cell score, while a high Immunoscore was associated with a lower number of metastases. Antiepidermal growth factor receptor treatment modified immune gene expression and significantly increased T cell densities in the metastasis core. The predictive accuracy of the Immunoscore from a single biopsy was superior to the one of programmed cell death ligand 1 (PD-L1). The immune phenotype of the least-infiltrated metastasis had a stronger association with patient outcome than other metastases.

机译：转移性结肠直肠癌的治疗基于患者在患者内均匀的假设。我们量化了603种全载转移的免疫细胞类型和222名患者的原发性结肠直肠癌。初级病变和同步和同赤转移，具有异质免疫渗透和突变多样性。小转移频繁具有低免疫验收和T和B细胞评分，而高免疫摩托与较低的转移相关。抗癫痫药物生长因子受体治疗改性免疫基因表达，显着增加了转移核心的T细胞密度。从单个活组织检查的免疫透视的预测精度优于编程的细胞死亡配体1（PD-L1）中的一种。最少渗透转移的免疫表型与患者结果具有比其他转移更强。

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《Cancer Cell》 |2018年第6期|共18页
作者
Van den Eynde Marc; Mlecnik Bernhard; Bindea Gabriela; Fredriksen Tessa; Church Sarah E.; Lafontaine Lucie; Haicheur Nacilla; Marliot Florence; Angelova Mihaela; Vasaturo Angela; Bruni Daniela; Jouret-Mourin Anne; Baldin Pamela; Huyghe Nicolas; Haustermans Karin; Debucquoy Annelies; Van Cutsem Eric; Gigot Jean-Francois; Hubert Catherine; Kartheuser Alex; Remue Christophe; Leonard Daniel; Valge-Archer Viia; Pages Franck; Machiels Jean-Pascal; Galon Jerome;
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作者单位

Catholic Univ Louvain Dept Med Oncol Clin Univ St Luc Inst Roi Albert II B-1200 Brussels Belgium;

Univ Paris Diderot Univ Paris Descartes Sorbonne Paris Cite INSERM Lab Integrat Canc Immunol;

Univ Paris Diderot Univ Paris Descartes Sorbonne Paris Cite INSERM Lab Integrat Canc Immunol;

Univ Paris Diderot Univ Paris Descartes Sorbonne Paris Cite INSERM Lab Integrat Canc Immunol;

Univ Paris Diderot Univ Paris Descartes Sorbonne Paris Cite INSERM Lab Integrat Canc Immunol;

Univ Paris Diderot Univ Paris Descartes Sorbonne Paris Cite INSERM Lab Integrat Canc Immunol;

HEGP AP HP Dept Immunol F-75015 Paris France;

Univ Paris Diderot Univ Paris Descartes Sorbonne Paris Cite INSERM Lab Integrat Canc Immunol;

Univ Paris Diderot Univ Paris Descartes Sorbonne Paris Cite INSERM Lab Integrat Canc Immunol;

Univ Paris Diderot Univ Paris Descartes Sorbonne Paris Cite INSERM Lab Integrat Canc Immunol;

Univ Paris Diderot Univ Paris Descartes Sorbonne Paris Cite INSERM Lab Integrat Canc Immunol;

Catholic Univ Louvain Dept Med Oncol Clin Univ St Luc Inst Roi Albert II B-1200 Brussels Belgium;

Catholic Univ Louvain Dept Med Oncol Clin Univ St Luc Inst Roi Albert II B-1200 Brussels Belgium;

Catholic Univ Louvain Dept Med Oncol Clin Univ St Luc Inst Roi Albert II B-1200 Brussels Belgium;

Katholieke Univ Leuven Lab Expt Radiotherapy Dept Oncol B-3000 Leuven Belgium;

Katholieke Univ Leuven Lab Expt Radiotherapy Dept Oncol B-3000 Leuven Belgium;

Univ Hosp Leuven Dept Gastroenterol B-3000 Leuven Belgium;

Catholic Univ Louvain Dept Med Oncol Clin Univ St Luc Inst Roi Albert II B-1200 Brussels Belgium;

Catholic Univ Louvain Dept Med Oncol Clin Univ St Luc Inst Roi Albert II B-1200 Brussels Belgium;

Catholic Univ Louvain Dept Med Oncol Clin Univ St Luc Inst Roi Albert II B-1200 Brussels Belgium;

Catholic Univ Louvain Dept Med Oncol Clin Univ St Luc Inst Roi Albert II B-1200 Brussels Belgium;

Catholic Univ Louvain Dept Med Oncol Clin Univ St Luc Inst Roi Albert II B-1200 Brussels Belgium;

AstraZeneca Cambridge CB2 0AA England;

Univ Paris Diderot Univ Paris Descartes Sorbonne Paris Cite INSERM Lab Integrat Canc Immunol;

Catholic Univ Louvain Dept Med Oncol Clin Univ St Luc Inst Roi Albert II B-1200 Brussels Belgium;

Univ Paris Diderot Univ Paris Descartes Sorbonne Paris Cite INSERM Lab Integrat Canc Immunol;

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专利

1. The Link between the Multiverse of Immune Microenvironments in Metastases and the Survival of Colorectal Cancer Patients [J] . Van den Eynde Marc, Mlecnik Bernhard, Bindea Gabriela, Cancer Cell . 2018,第6期

机译：转移中的免疫微环境多层与结直肠癌患者的存活之间的联系
2. Assessment of intratumor immune-microenvironment in colorectal cancers with extranodal extension of nodal metastases [J] . Matteo Fassan, Luca Vianello, Diana Sacchi, Cancer Cell International . 2018,第1期

机译：结外转移的结外扩展对大肠癌肿瘤内免疫微环境的评估
3. Single-cell transcriptome analysis reveals tumor immune microenvironment heterogenicity and granulocytes enrichment in colorectal cancer liver metastases [J] . Zhang Yunbin, Song Jingjing, Zhao Zhongwei, Cancer letters . 2020,第1期

机译：单细胞转录组分析显示肿瘤免疫微环境异质性和粒细胞富集在结肠直肠癌肝脏转移中的富集
4. Survival Benefit of Pelvic Exenteration for Locally Advanced Colorectal Cancer with Lymph Node Metastases [C] . J. Hida, T. Yoshifuji, F. Sugiura, International Society of University Colon and Rectal Surgeons . 2008

机译：淋巴结转移盆腔盆腔盆腔盆腔出生的生存效益
5. Cost-effectiveness of imaging and surgery in patients with colorectal cancer liver metastases. [D] . Gazelle, Guy Scott. 1999

机译：大肠癌肝转移患者影像和手术的成本效益。
6. Multiverse of immune microenvironment in metastatic colorectal cancer [O] . Marc Van den Eynde, Bernhard Mlecnik, Gabriela Bindea, 2020

机译：转移性结直肠癌中免疫微环境的多样性
7. Multiverse of immune microenvironment in metastatic colorectal cancer [O] . Marc Van den Eynde, Bernhard Mlecnik, Gabriela Bindea, 2020

机译：转移性结直肠癌中免疫微环境的多样性

The Link between the Multiverse of Immune Microenvironments in Metastases and the Survival of Colorectal Cancer Patients

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