Cooperation between Constitutive and Inducible Chemokines Enables T Cell Engraftment and Immune Attack in Solid Tumors

Dangaj Denarda; Bruand Marine; Grimm Alizee J.; Ronet Catherine; Barras David; Duttagupta Priyanka A.; Lanitis Evripidis; Duraiswamy Jaikumar; Tanyi Janos L.; Benencia Fabian; Conejo-Garcia Jose; Ramay Hena R.; Montone Kathleen T.; Powell Daniel J. Jr.; Gimotty Phyllis A.; Facciabene Andrea; Jackson Donald G.; Weber Jeffrey S.; Rodig Scott J.; Hodi Stephen F.; Kandalaft Lana E.; Irving Melita; Zhang Lin; Foukas Periklis; Rusakiewicz Sylvie; Delorenzi Mauro; Coukos George

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Cooperation between Constitutive and Inducible Chemokines Enables T Cell Engraftment and Immune Attack in Solid Tumors

机译：组成型和诱导趋化因子之间的合作使得能够在实体肿瘤中进行细胞植入和免疫发作

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We investigated the role of chemokines in regulating T cell accumulation in solid tumors. CCL5 and CXCL9 overexpression was associated with CD8(+) T cell infiltration in solid tumors. T cell infiltration required tumor cell-derived CCL5 and was amplified by IFN-gamma-inducible, myeloid cell-secreted CXCL9. CCL5 and CXCL9 coexpression revealed immunoreactive tumors with prolonged survival and response to checkpoint blockade. Loss of CCL5 expression in human tumors was associated with epigenetic silencing through DNA methylation. Reduction of CCL5 expression caused tumor-infiltrating lymphocyte (TIL) desertification, whereas forced CCL5 expression prevented Cxc/9 expression and TILs loss, and attenuated tumor growth in mice through IFN-gamma. The cooperation between tumor-derived CCL5 and IFN-gamma-inducible CXCR3 ligands secreted by myeloid cells is key for orchestrating T cell infiltration in immunoreactive and immunoresponsive tumors.

机译：我们调查了趋化因子在调节实体肿瘤中的T细胞积累方面的作用。 CCL5和CXCL9过表达与固体瘤中的CD8（+）T细胞浸润有关。 T细胞浸润需要肿瘤细胞衍生的CCl5，并通过IFN-Gamma-Invucible，髓样细胞分泌的CXCl9扩增。 CCL5和CXCL9共表达揭示了免疫反应性肿瘤，延长存活率和对检查点封闭的反应。人肿瘤中CCL5表达的丧失与通过DNA甲基化的表观遗传沉默有关。 CCL5表达的还原引起肿瘤浸润淋巴细胞（TIL）荒漠化，而强制性的CCL5表达可防止CXC / 9表达和直到损失，并通过IFN-γ在小鼠中减弱肿瘤生长。髓样细胞分泌的肿瘤衍生的CCL5和IFN-γ-诱导的CXCR3配体的合作是在免疫反应和免疫常用肿瘤中锻炼T细胞浸润的关键。

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来源
《Cancer Cell》 |2019年第6期|共26页
作者
Dangaj Denarda; Bruand Marine; Grimm Alizee J.; Ronet Catherine; Barras David; Duttagupta Priyanka A.; Lanitis Evripidis; Duraiswamy Jaikumar; Tanyi Janos L.; Benencia Fabian; Conejo-Garcia Jose; Ramay Hena R.; Montone Kathleen T.; Powell Daniel J. Jr.; Gimotty Phyllis A.; Facciabene Andrea; Jackson Donald G.; Weber Jeffrey S.; Rodig Scott J.; Hodi Stephen F.; Kandalaft Lana E.; Irving Melita; Zhang Lin; Foukas Periklis; Rusakiewicz Sylvie; Delorenzi Mauro; Coukos George;
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作者单位

Univ Lausanne Ludwig Inst Canc Res CH-1066 Lausanne Switzerland;

Univ Lausanne Ludwig Inst Canc Res CH-1066 Lausanne Switzerland;

Univ Lausanne Ludwig Inst Canc Res CH-1066 Lausanne Switzerland;

Univ Lausanne Ludwig Inst Canc Res CH-1066 Lausanne Switzerland;

Univ Lausanne Ludwig Inst Canc Res CH-1066 Lausanne Switzerland;

Univ Penn Ovarian Canc Res Ctr Perelman Sch Med Philadelphia PA 19104 USA;

Univ Lausanne Ludwig Inst Canc Res CH-1066 Lausanne Switzerland;

Univ Penn Ovarian Canc Res Ctr Perelman Sch Med Philadelphia PA 19104 USA;

Univ Penn Ovarian Canc Res Ctr Perelman Sch Med Philadelphia PA 19104 USA;

Ohio Univ Russ Coll Engn &

Technol Athens OH 45701 USA;

H Lee Moffitt Canc Ctr &

Res Inst Dept Immunol &

Gynecol Oncol Tampa FL 33612 USA;

SIB Swiss Inst Bioinformat CH-1015 Lausanne Switzerland;

Univ Penn Perelman Sch Med Dept Pathol &

Lab Med Philadelphia PA 19104 USA;

Univ Penn Ovarian Canc Res Ctr Perelman Sch Med Philadelphia PA 19104 USA;

Univ Penn Perelman Sch Med Dept Biostat &

Epidemiol Philadelphia PA 19104 USA;

Univ Penn Ovarian Canc Res Ctr Perelman Sch Med Philadelphia PA 19104 USA;

Bristol Myers Squibb Princeton NJ 08540 USA;

NYU Laura &

Isaac Perlmutter Canc Ctr 522 First Ave Room 1310 Smilow Bldg New York NY 10016 USA;

Brigham &

Womens Hosp Dept Pathol 75 Francis St Boston MA 02115 USA;

Dana Farber Canc Inst Ctr Immunooncol Boston MA 02215 USA;

Univ Lausanne Ludwig Inst Canc Res CH-1066 Lausanne Switzerland;

Univ Lausanne Ludwig Inst Canc Res CH-1066 Lausanne Switzerland;

Univ Penn Ovarian Canc Res Ctr Perelman Sch Med Philadelphia PA 19104 USA;

Univ Lausanne Ludwig Inst Canc Res CH-1066 Lausanne Switzerland;

Univ Lausanne Ludwig Inst Canc Res CH-1066 Lausanne Switzerland;

Univ Lausanne Ludwig Inst Canc Res CH-1066 Lausanne Switzerland;

Univ Lausanne Ludwig Inst Canc Res CH-1066 Lausanne Switzerland;

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正文语种 eng
中图分类肿瘤学;
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专利

1. Cooperation between Constitutive and Inducible Chemokines Enables T Cell Engraftment and Immune Attack in Solid Tumors [J] . Dangaj Denarda, Bruand Marine, Grimm Alizee J., Cancer Cell . 2019,第6期

机译：组成型和诱导趋化因子之间的合作使得能够在实体肿瘤中进行细胞植入和免疫发作
2. P06.03?C-C chemokine receptor 8 tumor-directed recruitment enables CAR T cells to reject solid tumors [J] . BL Cadilha, K Dorman, D Huynh, Journal for ImmunoTherapy of Cancer . 2020,第Suppla2期

机译：p06.03？C-C趋化因子受体8肿瘤定向招聘使得汽车T细胞拒绝实体瘤
3. Heat Shock Protein 70, Released from Heat-Stressed Tumor Cells, Initiates Antitumor Immunity by Inducing Tumor Cell Chemokine Production and Activating Dendritic Cells via TLR4 Pathway [J] . Taoyong Chen, Jun Guo, Chaofeng Han, The journal of immunology . 2009,第3期

机译：从热应激的肿瘤细胞释放的热休克蛋白70，通过诱导肿瘤细胞趋化因子的产生和通过TLR4途径激活树突状细胞来启动抗肿瘤免疫。
4. Photodynamic therapy stimulates anti-tumor immune response in mouse models: the role of regulatory T-cells, anti-tumor antibodies, and immune attack on brain metastases [C] . Fatma Vatansever, Masayoshi Kawakubo, Hoon Chung, Biophotonics and immune responses VIII . 2013

机译：光动力疗法在小鼠模型中刺激抗肿瘤免疫反应：调节性T细胞，抗肿瘤抗体的作用以及对脑转移瘤的免疫攻击
5. IMMUNE RESPONSE TO ULTRAVIOLET-INDUCED TUMORS: TRANSPLANTATION IMMUNITY AND LYMPHOCYTE POPULATIONS EXHIBITING ANTI-TUMOR ACTIVITY (CYTOLYTIC T, CLONES, NATURAL KILLER CELLS). [D] . STREETER, PHILIP REEL. 1985

机译：对紫外线诱导的肿瘤的免疫反应：移植免疫和具有抗肿瘤活性的淋巴细胞（细胞分裂性T，克隆，天然杀伤细胞）。
6. Therapeutic T cells induce tumor-directed chemotaxis of innate immune cells through tumor-specific secretion of chemokines and stimulation of B16BL6 melanoma to secrete chemokines [O] . Hauke Winter, Natasja K van den Engel, Dominik Rüttinger, 2007

机译：治疗性T细胞通过肿瘤特异性的趋化因子分泌和刺激B16BL6黑色素瘤分泌趋化因子来诱导先天免疫细胞的肿瘤定向趋化性
7. Therapeutic T cells induce tumor-directed chemotaxis of innate immune cells through tumor-specific secretion of chemokines and stimulation of B16BL6 melanoma to secrete chemokines [O] . Fox Bernard A, Löhe Florian, Poehlein Christian H, 2007

机译：治疗性T细胞通过肿瘤特异性的趋化因子分泌和刺激B16BL6黑色素瘤分泌趋化因子来诱导先天免疫细胞的肿瘤定向趋化性
8. Targeted Disruption of Tumor-Derived Chemokine Synthesis and Reversal of Tumor-Induced Immune Suppression [R] . Kurt, R. A. 2004

机译：靶向破坏肿瘤衍生的趋化因子合成和逆转肿瘤诱导的免疫抑制

Cooperation between Constitutive and Inducible Chemokines Enables T Cell Engraftment and Immune Attack in Solid Tumors

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