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首页> 外文期刊>Cancer Cell >Atypical Teratoid/Rhabdoid Tumors Are Comprised of Three Epigenetic Subgroups with Distinct Enhancer Landscapes
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Atypical Teratoid/Rhabdoid Tumors Are Comprised of Three Epigenetic Subgroups with Distinct Enhancer Landscapes

机译：非典型Teratoid / Rhabdoid肿瘤由三个具有不同增强剂景观的表观遗传亚组组成

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摘要

Atypical teratoid/rhabdoid tumor (ATRT) is one of the most common brain tumors in infants. Although the prognosis of ATRT patients is poor, some patients respond favorably to current treatments, suggesting molecular inter-tumor heterogeneity. To investigate this further, we genetically and epigenetically analyzed 192 ATRTs. Three distinct molecular subgroups of ATRTs, associated with differences in demographics, tumor location, and type of SMARCB1 alterations, were identified. Whole-genome DNA and RNA sequencing found no recurrent mutations in addition to SMARCB1 that would explain the differences between subgroups. Whole-genome bisulfite sequencing and H3K27Ac chromatin-immunoprecipitation sequencing of primary tumors, however, revealed clear differences, leading to the identification of subgroup-specific regulatory networks and potential therapeutic targets.
机译：非典型Teratoid / Rhabdoid肿瘤（ATRT）是婴儿中最常见的脑肿瘤之一。 虽然ATRT患者的预后差，但有些患者对目前的治疗有利，暗示分子肿瘤间异质性。 为了进一步调查这一点，我们遗传地和表述192个atrts。 鉴定了三个不同的分子亚组，与人口统计数据，肿瘤位置和SMARCB1改变的差异相关的atrts相关。 除了SMARCB1之外，全基因组DNA和RNA测序还发现了分解突变，所述SMARCB1将解释亚组之间的差异。 然而，全基因组亚硫酸氢盐测序和原发性肿瘤的H3K27AC染色质 - 免疫沉淀序列揭示了明显的差异，导致亚组特异性监管网络和潜在治疗目标的鉴定。

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  • 来源
    《Cancer Cell》 |2016年第3期|共15页
  • 作者

    Johann Pascal D.; Erkek Serap; Zapatka Marc; Kerl Kornelius; Buchhalter Ivo; Hovestadt Volker; Jones David T. W.; Sturm Dominik; Hermann Carl; Wang Maia Segura; Korshunov Andrey; Rhyzova Marina; Groebner Susanne; Brabetz Sebastian; Chavez Lukas; Bens Susanne; Groeschel Stefan; Kratochwil Fabian; Wittmann Andrea; Sieber Laura; Geoerg Christina; Wolf Stefan; Beck Katja; Oyen Florian; Capper David; van Sluis Peter; Volckmann Richard; Koster Jan; Versteeg Rogier; von Deimling Andreas; Milde Till; Witt Olaf; Kulozik Andreas E.; Ebinger Martin; Shalaby Tarek; Grotzer Michael; Sumerauer David; Zamecnik Josef; Mora Jaume; Jabado Nada; Taylor Michael D.; Huang Annie; Aronica Eleonora; Bertoni Anna; Radlwimmer Bernhard; Pietsch Torsten; Schueller Ulrich; Schneppenheim Reinhard; Northcott Paul A.; Korbel Jan O.; Siebert Reiner; Fruehwald Michael C.; Lichter Peter; Eils Roland; Gajjar Amar; Hasselblatt Martin; Pfister Stefan M.; Kool Marcel;

  • 作者单位

    German Canc Res Ctr Div Pediat Neurooncol Neuenheimer Feld 280 D-69120 Heidelberg Germany;

    German Canc Res Ctr Div Pediat Neurooncol Neuenheimer Feld 280 D-69120 Heidelberg Germany;

    German Canc Res Ctr Core Ctr Heidelberg D-69120 Heidelberg Germany;

    Univ Childrens Hosp Muenster Dept Pediat Hematol &

    Oncol D-48149 Munster Germany;

    German Canc Res Ctr Div Theoret Bioinformat D-69120 Heidelberg Germany;

    German Canc Res Ctr Core Ctr Heidelberg D-69120 Heidelberg Germany;

    German Canc Res Ctr Div Pediat Neurooncol Neuenheimer Feld 280 D-69120 Heidelberg Germany;

    German Canc Res Ctr Div Pediat Neurooncol Neuenheimer Feld 280 D-69120 Heidelberg Germany;

    German Canc Res Ctr Div Theoret Bioinformat D-69120 Heidelberg Germany;

    European Mol Biol Lab Genome Biol Unit D-69117 Heidelberg Germany;

    Univ Heidelberg Hosp Dept Neuropathol D-69120 Heidelberg Germany;

    Burdenko Neurosurg Inst Dept Neuropathol Moscow 125047 Russia;

    German Canc Res Ctr Div Pediat Neurooncol Neuenheimer Feld 280 D-69120 Heidelberg Germany;

    German Canc Res Ctr Div Pediat Neurooncol Neuenheimer Feld 280 D-69120 Heidelberg Germany;

    German Canc Res Ctr Div Pediat Neurooncol Neuenheimer Feld 280 D-69120 Heidelberg Germany;

    Natl Ctr Tumorerkrankungen Div Translat Oncol D-69120 Heidelberg Germany;

    German Canc Res Ctr Div Pediat Neurooncol Neuenheimer Feld 280 D-69120 Heidelberg Germany;

    German Canc Res Ctr Div Pediat Neurooncol Neuenheimer Feld 280 D-69120 Heidelberg Germany;

    German Canc Res Ctr Div Pediat Neurooncol Neuenheimer Feld 280 D-69120 Heidelberg Germany;

    Natl Ctr Tumorerkrankungen Div Translat Oncol D-69120 Heidelberg Germany;

    German Canc Res Ctr Genom &

    Proteom Core Facil D-69120 Heidelberg Germany;

    German Canc Res Ctr Core Ctr Heidelberg D-69120 Heidelberg Germany;

    Univ Hosp Hamburg Eppendorf Dept Pediat Hematol &

    Oncol D-20246 Hamburg Germany;

    Univ Heidelberg Hosp Dept Neuropathol D-69120 Heidelberg Germany;

    Univ Amsterdam Acad Med Ctr Dept Oncogen Meibergdreef 9 NL-1105 AZ Amsterdam Netherlands;

    Univ Amsterdam Acad Med Ctr Dept Oncogen Meibergdreef 9 NL-1105 AZ Amsterdam Netherlands;

    Univ Amsterdam Acad Med Ctr Dept Oncogen Meibergdreef 9 NL-1105 AZ Amsterdam Netherlands;

    Univ Amsterdam Acad Med Ctr Dept Oncogen Meibergdreef 9 NL-1105 AZ Amsterdam Netherlands;

    Univ Heidelberg Hosp Dept Neuropathol D-69120 Heidelberg Germany;

    Univ Heidelberg Hosp Dept Pediat Hematol &

    Oncol D-69120 Heidelberg Germany;

    Univ Heidelberg Hosp Dept Pediat Hematol &

    Oncol D-69120 Heidelberg Germany;

    Univ Heidelberg Hosp Dept Pediat Hematol &

    Oncol D-69120 Heidelberg Germany;

    Univ Tubingen Dept Gen Pediat Hematol &

    Oncol D-72076 Tubingen Germany;

    Univ Childrens Hosp Childrens Res Ctr Dept Neurooncol CH-8032 Zurich Switzerland;

    Univ Childrens Hosp Childrens Res Ctr Dept Neurooncol CH-8032 Zurich Switzerland;

    Charles Univ Prague Dept Pediat Hematol &

    Oncol Prague 15006 Czech Republic;

    Charles Univ Prague Univ Hosp Motol Fac Med 2 Dept Pathol &

    Mol Med Prague 15006 Czech Republic;

    Hosp San Joan de Deu Childrens Hosp Dept Hematol &

    Oncol Barcelona 08950 Spain;

    McGill Univ Ctr Hlth Res Inst Dept Pediat Montreal PQ H3A 1A4 Canada;

    Univ Toronto Hosp Sick Children Arthur &

    Sonia Labatt Brain Tumor Res Ctr Toronto ON M5G 0A4;

    Univ Toronto Hosp Sick Children Arthur &

    Sonia Labatt Brain Tumor Res Ctr Toronto ON M5G 0A4;

    Acad Med Ctr Dept Neuropathol NL-20246 Amsterdam Netherlands;

    German Canc Res Ctr Div Mol Genet D-69120 Heidelberg Germany;

    German Canc Res Ctr Div Mol Genet D-69120 Heidelberg Germany;

    Univ Bonn Dept Neuropathol D-53127 Bonn Germany;

    Univ Munich Ctr Neuropathol Marchioninistr 15 D-81377 Munich Germany;

    Univ Hosp Hamburg Eppendorf Dept Pediat Hematol &

    Oncol D-20246 Hamburg Germany;

    German Canc Res Ctr Div Pediat Neurooncol Neuenheimer Feld 280 D-69120 Heidelberg Germany;

    European Mol Biol Lab Genome Biol Unit D-69117 Heidelberg Germany;

    Inst Human Genet D-24105 Kiel Germany;

    Childrens Hosp Augsburg Swabian Childrens Canc Ctr D-86156 Augsburg Germany;

    German Canc Res Ctr Core Ctr Heidelberg D-69120 Heidelberg Germany;

    German Canc Res Ctr Div Theoret Bioinformat D-69120 Heidelberg Germany;

    St Jude Childrens Res Hosp 332 N Lauderdale St Memphis TN 38105 USA;

    Univ Hosp Munster Inst Neuropathol D-48149 Munster Germany;

    German Canc Res Ctr Div Pediat Neurooncol Neuenheimer Feld 280 D-69120 Heidelberg Germany;

    German Canc Res Ctr Div Pediat Neurooncol Neuenheimer Feld 280 D-69120 Heidelberg Germany;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 肿瘤学;
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