PPAR gamma: Welcoming the New Kid on the CML Stem Cell Block

Winger Beth Apsel; Shah Neil P.

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PPAR gamma: Welcoming the New Kid on the CML Stem Cell Block

机译：PPAR Gamma：欢迎CML干细胞块上的新孩子

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Recently, chronic myeloid leukemia (CML) patients already responding to treatment showed improved molecular responses with pioglitazone, presumably through PPAR gamma activation and CML stem cell eradication. Given data demonstrating deepening responses and successful treatment discontinuation with current therapy, the necessity for new therapies targeting CML stem cells to achieve cure is unclear.

机译：最近，已经应对治疗的慢性骨髓白血病（CML）患者显示出改善与吡格列酮的分子反应，大概是通过PPARγ活化和CML干细胞根除。给定数据展示深化反应和使用目前疗法停止的成功治疗，靶向CML干细胞的新疗法的必要性尚不清楚。

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《Cancer Cell》 |2015年第4期|共3页
作者
Winger Beth Apsel; Shah Neil P.;
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作者单位

Univ Calif San Francisco Dept Pediat Hematol Oncol San Francisco CA 94143 USA;

Univ Calif San Francisco Dept Med Div Hematol Oncol San Francisco CA 94143 USA;

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正文语种 eng
中图分类肿瘤学;
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1. Nuclear peroxisome proliferator activated receptor-gamma (PPARγ) as a therapeutic target to treat neurodegeneration and dependence elicited by drugs of abuse [J] . Roberto Ciccocioppo, Massimo Ubaldi 中国神经再生研究（英文版） . 2021,第005期
2. Expressions of GSK-3beta, Beta-Catenin and PPAR-Gamma in Medulloblastoma [J] . Xiong Zhang, Lu Si, Yu Li, 中国癌症研究（英文版） . 2009,第003期
3. PPAR gamma: Welcoming the New Kid on the CML Stem Cell Block [J] . Winger Beth Apsel, Shah Neil P. Cancer Cell . 2015,第4期

机译：PPARγ：欢迎CML干细胞块上的新孩子
4. Compound 48, a novel dual PPAR alpha/gamma ligand, inhibits the growth of human CML cell lines and enhances the anticancer-effects of imatinib. [J] . Bertz J, Zang C, Liu H, Leukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis . 2009,第5期

机译：化合物48是新型的双重PPARα/γ配体，可抑制人CML细胞系的生长并增强伊马替尼的抗癌作用。
5. DHA blocks TPA-induced cell invasion by inhibiting MMP-9 expression via suppression of the PPAR-gamma/NF-kappa B pathway in MCF-7 cells [J] . Hwang Jin-Ki, Yu Hong-Nu, Noh Eun-Mi, Oncology letters . 2017,第1期

机译：通过抑制MCF-7细胞中的PPAR-Gamma / NF-κB途径抑制MMP-9表达，DHA阻断TPA诱导的细胞侵袭
6. New In Vitro Strategy of Astrocytoma (Astrocytes-like) Cells Treated with Pioglitazone (PPAR gamma agonist) Offers Neuroprotection Against Nanoparticles-lnduced Cytotoxicity [C] . Yin Yin W. Wong, Ashvin Jaiswal, Vikas V. Dukhande, NSTI nanotechnology conference and expo;Nanotech conference expo;NSTI-Nanotech 2011;TechConnect world annual conference expo . 2011

机译：吡格列酮（PPARγ激动剂）治疗的星形细胞瘤（星形胶质细胞）细胞新的体外策略提供了针对纳米颗粒诱导的细胞毒性的神经保护作用
7. Functional genomic analysis of PPAR-gamma in human colorectal cancer cells. [D] . Bush, Craig Randall. 2007

机译：人类大肠癌细胞中PPAR-γ的功能基因组分析。
8. Combination Treatment with PPARγ Ligand and Its Specific Inhibitor GW9662 Downregulates BIS and 14-3-3 Gamma, Inhibiting Stem-Like Properties in Glioblastoma Cells [O] . Chang-Nim Im 2006

机译：PPARγ配体及其特异性抑制剂GW9662的联合治疗下调BIS和14-3-3γ，抑制胶质母细胞瘤细胞的茎样特性
9. PPARγ: Welcoming the New Kid on the CML Stem Cell Block [O] . Apsel Winger Beth, Shah Neil P. 2015

机译：PPARγ：欢迎新生的CML干细胞块

PPAR gamma: Welcoming the New Kid on the CML Stem Cell Block

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