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首页> 外文期刊>Cancer Cell >Genomic and Transcriptomic Profiling of Combined Hepatocellular and Intrahepatic Cholangiocarcinoma Reveals Distinct Molecular Subtypes
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Genomic and Transcriptomic Profiling of Combined Hepatocellular and Intrahepatic Cholangiocarcinoma Reveals Distinct Molecular Subtypes

机译：联合肝细胞癌和肝内胆管癌的基因组和转录组分析显示不同的分子亚型

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摘要

We performed genomic and transcriptomic sequencing of 133 combined hepatocellular and intrahepatic cholangiocarcinoma (cHCC-ICC) cases, including separate, combined, and mixed subtypes. Integrative comparison of cHCC-ICC with hepatocellular carcinoma and intrahepatic cholangiocarcinoma revealed that combined and mixed type cHCC-ICCs are distinct subtypes with different clinical and molecular features. Integrating laser microdissection, cancer cell fraction analysis, and single nucleus sequencing, we revealed both mono- and multiclonal origins in the separate type cHCC-ICCs, whereas combined and mixed type cHCC-ICCs were all monoclonal origin. Notably, cHCC-ICCs showed significantly higher expression of Nestin, suggesting Nestin may serve as a biomarker for diagnosing cHCC-ICC. Our results provide important biological and clinical insights into cHCC-ICC.
机译：我们进行了133种肝细胞癌和肝内胆管癌（CHCC-ICC）病例的基因组和转录组序列，包括分离，合并和混合亚型。 CHCC-ICC与肝细胞癌和肝内胆管癌的整合性比较显示，结合和混合式CHCC-ICC是具有不同临床和分子特征的不同亚型。 整合激光微生物，癌细胞分数分析和单核测序，我们揭示了单独的CHCC-ICC中的单态和多链条起源，而组合和混合式CHCC-ICC是所有单克隆源。 值得注意的是，CHCC-ICC表现出巢蛋白的显着高，表明巢蛋白可以用作诊断CHCC-ICC的生物标志物。 我们的结果为CHCC-ICC提供了重要的生物学和临床洞察。

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  • 来源
    《Cancer Cell》 |2019年第6期|共24页
  • 作者

    Xue Ruidong; Chen Lu; Zhang Chong; Fujita Masashi; Li Ruoyan; Yan Shu-Mei; Ong Choon Kiat; Liao Xiwen; Gao Qiang; Sasagawa Shota; Li Yanmeng; Wang Jincheng; Guo Hua; Huang Qi-Tao; Zhong Qian; Tan Jing; Qi Lisha; Gong Wenchen; Hong Zhixian; Li Meng; Zhao Jingmin; Peng Tao; Lu Yinying; Lim Kiat Hon Tony; Boot Arnoud; Ono Atushi; Chayama Kazuaki; Zhang Zemin; Rozen Steve George; Teh Bin Tean; Wang Xin Wei; Nakagawa Hidewaki; Zeng Mu-Sheng; Bai Fan; Zhang Ning;

  • 作者单位

    Peking Univ Hosp 1 Sch Life Sci Biomed Pioneering Innovat Ctr BIOPIC Beijing 100871 Peoples R;

    Tianjin Med Univ Canc Inst &

    Hosp Key Lab Canc Prevent &

    Therapy Tianjins Clin Res Ctr Canc Dept;

    Peking Univ Hosp 1 Sch Life Sci Biomed Pioneering Innovat Ctr BIOPIC Beijing 100871 Peoples R;

    RIKEN Ctr Integrat Med Sci Lab Canc Genom Yokohama Kanagawa 2300045 Japan;

    Peking Univ Hosp 1 Sch Life Sci Biomed Pioneering Innovat Ctr BIOPIC Beijing 100871 Peoples R;

    Sun Yat Sen Univ Ctr Canc Collaborat Innovat Ctr Canc Med State Key Lab Oncol South China;

    Natl Canc Ctr Singapore Div Cellular &

    Mol Res Lymphoma Genom Translat Res Lab Singapore 169610;

    Guangxi Med Univ Affiliated Hosp 1 Dept Hepatobiliary Surg Nanning 530021 Peoples R China;

    Fudan Univ Zhongshan Hosp Liver Canc Inst Dept Liver Surg &

    Transplantat Shanghai 200032;

    RIKEN Ctr Integrat Med Sci Lab Canc Genom Yokohama Kanagawa 2300045 Japan;

    Peking Univ Hosp 1 Sch Life Sci Biomed Pioneering Innovat Ctr BIOPIC Beijing 100871 Peoples R;

    Peking Univ Hosp 1 Sch Life Sci Biomed Pioneering Innovat Ctr BIOPIC Beijing 100871 Peoples R;

    Tianjin Med Univ Canc Inst &

    Hosp Lab Canc Cell Biol Tianjin 300060 Peoples R China;

    Sun Yat Sen Univ Ctr Canc Collaborat Innovat Ctr Canc Med State Key Lab Oncol South China;

    Sun Yat Sen Univ Ctr Canc Collaborat Innovat Ctr Canc Med State Key Lab Oncol South China;

    Sun Yat Sen Univ Ctr Canc Collaborat Innovat Ctr Canc Med State Key Lab Oncol South China;

    Tianjin Med Univ Canc Inst &

    Hosp Dept Pathol Tianjin 300060 Peoples R China;

    Tianjin Med Univ Canc Inst &

    Hosp Dept Pathol Tianjin 300060 Peoples R China;

    Beijing 302 Hosp Dept Hepatobiliary Surg Beijing 100039 Peoples R China;

    Beijing 302 Hosp Dept Ultrasonog Beijing 100039 Peoples R China;

    Beijing 302 Hosp Dept Pathol &

    Hepatol Beijing 100039 Peoples R China;

    Guangxi Med Univ Affiliated Hosp 1 Dept Hepatobiliary Surg Nanning 530021 Peoples R China;

    Beijing 302 Hosp Comprehens Liver Canc Ctr Beijing 100039 Peoples R China;

    Singapore Gen Hosp Dept Anat Pathol Singapore 169608 Singapore;

    Duke NUS Med Sch Ctr Computat Biol Singapore 169857 Singapore;

    Hiroshima Univ Grad Sch Biomed &

    Hlth Sci Dept Gastroenterol &

    Metab Hiroshima 7348553 Japan;

    Hiroshima Univ Grad Sch Biomed &

    Hlth Sci Dept Gastroenterol &

    Metab Hiroshima 7348553 Japan;

    Peking Univ Hosp 1 Sch Life Sci Biomed Pioneering Innovat Ctr BIOPIC Beijing 100871 Peoples R;

    Duke NUS Med Sch Ctr Computat Biol Singapore 169857 Singapore;

    Natl Canc Ctr Singapore Div Med Sci Lab Canc Epigenome Singapore 169610 Singapore;

    NCI Lan Human Carcinogenesis Ctr Canc Res Bethesda MD 20892 USA;

    RIKEN Ctr Integrat Med Sci Lab Canc Genom Yokohama Kanagawa 2300045 Japan;

    Sun Yat Sen Univ Ctr Canc Collaborat Innovat Ctr Canc Med State Key Lab Oncol South China;

    Peking Univ Hosp 1 Sch Life Sci Biomed Pioneering Innovat Ctr BIOPIC Beijing 100871 Peoples R;

    Peking Univ Hosp 1 Sch Life Sci Biomed Pioneering Innovat Ctr BIOPIC Beijing 100871 Peoples R;

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  • 正文语种 eng
  • 中图分类 肿瘤学;
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