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NAD+ Supplementation as a Novel Approach to cURIng HCC?

机译:NAD +补充作为康复HCC的新方法?

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摘要

In this issue of Cancer Cell, Tummala and colleagues demonstrate that unconventional prefoldin RPB5 interactor (URI) expression in hepatocytes leads to hepatocellular carcinoma (HCC) development by interacting with L-tryptophan/kynurenine/nicotinamide adenine dinucleotide (NAD+) metabolism. The results suggest that supplementation of NAD+ may be a prophylactic or therapeutic approach in HCC. In this issue of Cancer Cell, Tummala and colleagues demonstrate that Unconventional prefoldin RPB5 Interactor (URI) expression in hepatocytes leads to hepatocellular carcinoma (HCC) development by interacting with L-tryptophan/kynurenine/nicotinamide adenine dinucleotide (NAD+) metabolism. The results suggest that supplementation of NAD+ may be a prophylactic or therapeutic approach in HCC.
机译:在这个问题中,腹膜和同事证明,通过与L-Trotophan / kynurenine /烟酰胺腺嘌呤二核苷酸腺苷(NAD +)代谢相互作用,表明,肝细胞中的非传统预选RPB5交流剂(URI)表达导致肝细胞癌(HCC)发育。 结果表明,NAD +的补充可以是HCC中的预防或治疗方法。 在这个问题中,腹膜和同事证明,通过与L-Trotophan / kynurenine /烟酰胺腺嘌呤二核苷酸腺苷(NAD +)代谢相互作用,表明,肝细胞中的非传统预选RPB5交流剂(URI)表达导致肝细胞癌(HCC)发育。 结果表明,NAD +的补充可以是HCC中的预防或治疗方法。

著录项

  • 来源
    《Cancer Cell》 |2014年第6期|共2页
  • 作者

    MederackeI.; SchwabeR.F.;

  • 作者单位

    Department of Gastroenterology Hepatology and Endocrinology Hannover Medical School Carl-Neuberg;

    Department of Medicine Columbia University College of Physicians and Surgeons 1150 St. Nicolas;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 肿瘤学;
  • 关键词

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