Very CIN-ful: whole chromosome instability promotes tumor suppressor loss of heterozygosity.

Sotillo R; Schvartzman JM; Benezra R

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Very CIN-ful: whole chromosome instability promotes tumor suppressor loss of heterozygosity.

机译：非常Cin-Fure：全染色体不稳定性促进肿瘤抑制剂的杂合子丧失。

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Mechanisms by which whole chromosome instability lead to tumorigenesis have eluded the cancer research field. In this issue of Cancer Cell, Baker et al. show that CIN induced by a defective mitotic checkpoint, under certain genetic and tissue contexts, leads to accelerated loss of heterozygosity of a tumor suppressor gene.

机译：整个染色体不稳定性导致肿瘤发生的机制已经突出了癌症研究领域。在这个问题中癌细胞，Baker等人。表明，在某些遗传和组织背景下，有缺陷的有丝分型检查点引起的CIN，导致肿瘤抑制基因的杂合子的损失加速。

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《Cancer Cell》 |2009年第6期|共2页
作者
Sotillo R; Schvartzman JM; Benezra R;
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作者单位

Program in Cancer Biology and Genetics Memorial Sloan Kettering Cancer Center New York NY 10065 USA.;

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原文格式 PDF
正文语种 eng
中图分类肿瘤学;
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专利

1. Very CIN-ful: whole chromosome instability promotes tumor suppressor loss of heterozygosity. [J] . Sotillo R, Schvartzman JM, Benezra R Cancer Cell . 2009,第6期

机译：非常Cin-Fure：全染色体不稳定性促进肿瘤抑制剂的杂合子丧失。
2. Loss of Bard1, the Heterodimeric Partner of the Brca1 Tumor Suppressor, Results in Early Embryonic Lethality and Chromosomal Instability [J] . Ellen E. McCarthy, Julide T. Celebi, Richard Baer, Molecular and Cellular Biology . 2003,第14期

机译：Brca1肿瘤抑制物异源二聚体伴侣Bard1的缺失导致早期胚胎致死率和染色体不稳定
3. DLC1 is a chromosome 8p tumor suppressor whose loss promotes hepatocellular carcinoma. [J] . Xue W, Krasnitz A, Lucito R, Genes and Development: a Journal Devoted to the Molecular Analysis of Gene Expression in Eukaryotes, Prokaryotes, and Viruses . 2008,第11期

机译：DLC1是染色体8p肿瘤抑制因子，其丢失会促进肝细胞癌。
4. Chromosomal deletions and tumor suppressor genes in prostate cancer [C] . World Congress on Heart Failure--Mechanisms and Management . 2002

机译：前列腺癌中的染色体缺失和肿瘤抑制基因
5. Genetic or HPV-Induced CENP-E Loss Promotes Chromosomal Instability and Protects Against Tumor Growth in p53-Deficient Cancers [D] . Funk, Laura C. 2020

机译：遗传或HPV诱导的CENP-E损失促进染色体不稳定性并防止P53缺陷癌症的肿瘤生长
6. Very CIN-ful: Whole Chromosome Instability Promotes Tumor Suppressor Loss of Heterozygosity [O] . Rocio Sotillo, Juan-Manuel Schvartzman, Robert Benezra -1

机译：非常CIN-FUL：整条染色体不稳定性促进杂合性抑癌损失
7. Very CIN-ful: Whole Chromosome Instability Promotes Tumor Suppressor Loss of Heterozygosity [O] . Sotillo Rocio, Schvartzman Juan-Manuel, Benezra Robert 2009

机译：CIN值很高：整个染色体不稳定会促进肿瘤抑制杂合性的丧失

Very CIN-ful: whole chromosome instability promotes tumor suppressor loss of heterozygosity.

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