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首页> 外文期刊>Balkan journal of medical genetics: BJMG >ANALYSIS OF THE PPARD GENE EXPRESSION LEVEL CHANGES IN FOOTBALL PLAYERS IN RESPONSE TO THE TRAINING CYCLE
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ANALYSIS OF THE PPARD GENE EXPRESSION LEVEL CHANGES IN FOOTBALL PLAYERS IN RESPONSE TO THE TRAINING CYCLE

机译：训练周期响应足球运动员PPARD基因表达水平的分析

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摘要

The PPARD gene codes protein that belongs to the peroxisome proliferator-activated receptor (PPAR) family engaged in a variety of biological processes, including lipid metabolism in muscle cells. In this study, we assess the relationship between PPARD gene expression lipid metabolism parameters and the variation of the PPARD gene expression before (T-1) and after 12 hours of training (T-2) sessions in a group of football players. Peripheral blood lymphocytes were obtained from 22 football players (17.5 +/- 0.7 years, 178 +/- 0.7 cm, 68.05 +/- 9.18 kg). The PR4RD gene expression, analyzed by quantitative poly merase chain reaction (qPCR), was significantly higher after T-2 (p = 0.0006). Moreover, at the end of the training cycle, there was a significant decrease in relative fat tissue (FAT) (%) (p = 0.01) and absolute FAT (kg) (p = 0.01). A negative correlation was observed between absolute FAT (kg) and PPARD gene expression level in T-2 (p = 0.03). The levels of cholesterol and triglyceride (TG) fractions were not significantly different (p >0.05) before and after training. No significant relationship between PPARD expression and cholesterol or TG levels was found. We found that physical training affects PPARD expression. Moreover, the negative correlation between PPARD expression and absolute FAT (kg) level may be indicative of the contribution of PPARD in metabolic adaptation to increased lipid uptake that can be used to control the body composition of athletes.
机译：属于过氧化物酶体增殖物激活的受体（PPAR）家族的PPARD基因编码蛋白从事各种生物过程，包括肌肉细胞中的脂质代谢。在这项研究中，我们评估了PPARD基因表达脂质代谢参数的关系和PPARD基因表达的变异（T-1）和一组足球运动员中的12小时训练（T-2）课程。外周血淋巴细胞从22名足球运动员获得（17.5 +/- 0.7岁，178 +/- 0.7厘米，68.05 +/- 9.18千克）。通过定量聚合物纯粹链反应（QPCR）分析的PR4RD基因表达（QPCR）在T-2（P = 0.0006）后明显高。此外，在训练循环结束时，相对脂肪组织（脂肪）（％）（p = 0.01）和绝对脂肪（kg）存在显着降低（p = 0.01）。在T-2中的绝对脂肪（kg）和ppard基因表达水平之间观察到负相关（p = 0.03）。在训练之前和之后，胆固醇和甘油三酯（Tg）级分的水平没有显着差异（p> 0.05）。发现PPARD表达和胆固醇或TG水平之间没有显着的关系。我们发现物理训练会影响PPARD表达。此外，PPARD表达和绝对脂肪（kg）水平之间的负相关性可以指示PPARt在代谢适应中的贡献，以增加可用于控制运动员的身体组成的脂质摄取。

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