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首页> 外文期刊>Balkan journal of medical genetics: BJMG >ASSOCIATION BETWEEN INHERITED THROMBOPHILIA IN PREGNANCY AND MICRONUCLEUS FREQUENCY IN PERIPHERAL BLOOD LYMPHOCYTES
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ASSOCIATION BETWEEN INHERITED THROMBOPHILIA IN PREGNANCY AND MICRONUCLEUS FREQUENCY IN PERIPHERAL BLOOD LYMPHOCYTES

机译：外周血淋巴细胞妊娠期妊娠血栓血管血管血管频率的关系

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摘要

The aim of this study was to determine possible predictors of an increased frequency of micronucleus (MN) and the impact of thrombophilia on the chromosomal instability in peripheral blood lymphocytes (PBL) of pregnant women in their first trimester. This study was designed as a case-control study on 74 pregnant women. It was performed in the gestational age of 11 to 14 weeks, when blood samples were collected and incubated for 72 hours. The individual MN frequency in PBL was measured by cytokinesis- block micronucleus (CBMN) assay. Women were grouped in control group [ 4 MN/1000 BN cells). Potential mutagenic effects of exogenous/endogenous factors in pregnant women were analyzed. By analyzing the given results, it can be concluded that pregnant women with thrombophilia have 26.69-times more chance of having a frequency of > 4 MN/1000 BN than pregnant women with no thrombophilia. Our research was primarily aimed at showing that the presence of thrombophilia was a statistically important predictor of an increased MN frequency in pregnant women and it can predict about one-third of the total variance in MN frequency in the studied population.
机译：本研究的目的是确定微核（Mn）频率增加的可能预测因子以及血栓血液粒细胞对孕妇在孕妇的周围血液淋巴细胞（PBL）中的染色体不稳定的影响。该研究被设计为对74名孕妇的病例对照研究。当收集血液样品并孵育72小时时，它在11至14周的妊娠期进行。通过细胞因子嵌段微核（CBMN）测定法测量PBL中的个体MN频率。妇女在对照组中进行分组[4mn / 1000bn细胞）。分析了孕妇外源/内源性因素的潜在致突变作用。通过分析给定的结果，可以得出结论，孕妇血栓管患者的血栓患者比孕妇没有血栓形成的妇女的频率为> 4mn / 1000英镑的频率。我们的研究主要旨在表明血栓性血液醇的存在是孕妇中MN频率增加的统计学上重要的预测因子，并且可以预测研究人群中MN频率总方差的三分之一。

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