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首页> 外文期刊>Cancer letters >Glypican-5 is a novel metastasis suppressor gene in non-small cell lung cancer
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Glypican-5 is a novel metastasis suppressor gene in non-small cell lung cancer

机译：甘蓬松-5是非小细胞肺癌中的新型转移抑制基因

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摘要

Lung cancer is the most common cause of cancer death worldwide, with increasingly high death rates in Europe, North America, and Eastern Asia [ 1 ]. Particularly serious in China, lung cancer incidence has increased by 465% during the past 30 years, and more than 1 million lung cancer patients are predicted to will be diagnosed each year by the year 2025 [2]. Recent data from the IASLC indicated that 65% of non-small cell lung cancer (NSCLC) patients were classified at stage IIIA-IV, and their overall 5-year survival rate remains lower than 15%, even if they received systematic therapies [3]. Tumor progression and metastasis are the leading causes of death in these advanced NSCLC patients [4]. Therefore, screening lung cancer metastasis-related genes and exploring new pathways is critical for the development of both novel biomarkers and therapeutic targets of NSCLC.
机译：肺癌是全世界癌症死亡的最常见原因，欧洲，北美和东亚的死亡率越来越高[1]。 在中国特别严重，过去30岁，肺癌发病率增加了465％，预计每年将在2025年期间诊断超过100万肺癌患者[2]。 来自IASLC的最新数据表明，65％的非小细胞肺癌（NSCLC）患者在第IIIA期 - IV分类，即使他们接受系统疗法，它们的总体5年生存率仍然低于15％[3 ]。 肿瘤进展和转移是这些先进的NSCLC患者中死亡的主要原因[4]。 因此，筛选肺癌转移相关基因并探索新途径对于开发新型生物标志物和NSCLC治疗靶标至关重要。

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