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Marshaling the Translational Potential of MC1R for Precision Risk Assessment of Melanoma

机译：MC1R对黑色素瘤精确风险评估的翻译潜力

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摘要

Melanoma rates have been increasing in the United States, and neither primary (sun protection and avoidance) nor secondary (skin examination) prevention is practiced consistently, even by those with melanoma risk factors. Inherited variation at MC1R is a robust marker for increased risk of melanoma, even among individuals with “sun-resistant” phenotypes. Although MC1R conveys important information about inherited melanoma risk for a broad spectrum of individuals, concerns that MC1R feedback could have negative consequences, including increased distress about melanoma, inappropriate use of health services, and development of a false sense of security, are valid and require empirical examination. The time is right for high-quality research focusing on the translation of MC1R genotype into clinical and public health practice. If studies show MC1R genetic risk screening is effective at motivating behavior change, more melanomas may be detected at earliest stages for which surgical excision is highly curative or a large number of melanomas may be prevented altogether. While other genetic markers for melanoma susceptibility may emerge in the coming years, the burgeoning research agenda on the public health translational potential of MC1R genetic risk screening will inform and usefully advance current and future precision risk assessment of melanoma. Cancer Prev Res; 11(3); 121–4. ?2017 AACR .
机译：黑色素瘤率在美国越来越多，既不持续实践（阳光保护和避让）也不是次要（皮肤检查），甚至是黑色素瘤风险因素的危险因素。 MC1R的遗传变异是一种强大的标记，用于增加黑素瘤的风险，即使是具有“防晒”表型的个体。虽然MC1R传达了关于遗传性黑素瘤风险的重要信息，但令人担忧的是MC1R反馈可能产生负面后果，包括对黑素瘤的痛苦增加，不适当地使用卫生服务，以及虚假安全感的发展是有效的，需要经验考试。高质量研究的时候，重点是MC1R基因型转化为临床和公共卫生实践的高质量研究。如果研究表明MC1R遗传风险筛查在激励行为变化下有效，则可以在最早的阶段中检测更多的黑色素瘤，其外科切除是高度固化的或可以完全防止大量黑色素瘤。在未来几年可能出现对黑色素瘤的其他遗传标志物，但在未来几年中，MC1R遗传风险筛查公共卫生翻译潜力的蓬勃发展的研究议程将为MEANOMA提供通知和有限地推进当前和未来的精确风险评估。癌症prev res; 11（3）; 121-4。 ？2017年AACR。

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  • 来源
    《Cancer prevention research.》 |2018年第3期|共4页
  • 作者

    Peter A. Kanetsky; Jennifer L. Hay;

  • 作者单位

    Department of Cancer Epidemiology Moffitt Cancer Center and Research Institute Tampa Florida.;

    Department of Psychiatry and Behavioral Sciences Memorial Sloan Kettering Cancer Center New York;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 肿瘤学;
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