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首页> 外文期刊>Cancer prevention research. >JAK3 Variant, Immune Signatures, DNA Methylation, and Social Determinants Linked to Survival Racial Disparities in Head and Neck Cancer Patients
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JAK3 Variant, Immune Signatures, DNA Methylation, and Social Determinants Linked to Survival Racial Disparities in Head and Neck Cancer Patients

机译：JAK3变异，免疫签名，DNA甲基化和社会决定因素与头部和颈部癌症患者的生存种族差异相关联

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摘要

To inform novel personalized medicine approaches for race and socioeconomic disparities in head and neck cancer, we examined germline and somatic mutations, immune signatures, and epigenetic alterations linked to neighborhood determinants of health in Black and non-Latino White (NLW) patients with head and neck cancer. Cox proportional hazards revealed that Black patients with squamous cell carcinoma of head and neck (HNSCC) with PAX5 (P = 0.06) and PAX1 (P = 0.017) promoter methylation had worse survival than NLW patients, after controlling for education, zipcode, and tumor-node-metastasis stage (n = 118). We also found that promoter methylation of PAX1 and PAX5 (n = 78), was correlated with neighborhood characteristics at the zip-code level (P A germline mutation in JAK3, chr19:17954215 (protein P132T), in Black patients with HNSCC (n = 73; P 5 years), when compared with short-term survival (<2 years). We show bio-social determinants of health associated with survival in Black patients with HNSCC, which together with racial differences shown in germline mutations, somatic mutations, and TIL counts, suggests that contextual factors may significantly inform precision oncology services for diverse populations.
机译：为了告知头部和颈部癌症的种族和社会经济差异的小说的个性化医学方法，我们检查了与头部和非拉丁裔白人（NLW）患者的健康状况邻里决定簇相关的种系和躯体突变，免疫签名和表观遗传改变。颈癌。 Cox比例危害显示，具有PAX5（P = 0.06）和PAX1（P = 0.06）和PAX1（P = 0.017）启动子甲基化的黑色细胞癌的黑色患者比NLW患者在控制教育，ZIPCODE和肿瘤后越差 - 导月转移阶段（n = 118）。我们还发现PAX1和PAX5（n = 78）的启动子甲基化与邮政编码水平（JAK3，CHR19：17954215（蛋白质P132T）的邻域特征相关（在黑色HNSCC患者中（n = 73; p 5年），与短期存活（<2年）相比。我们展示了与HNSCC的黑色患者的生存生存生物社会的生物社会决定因素，其中与种种突变中显示的种族差异，躯体突变而且TIL计数表明，上下文因素可能会显着为各种群体提供精密肿瘤服务。

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  • 来源
    《Cancer prevention research.》 |2019年第4期|共16页
  • 作者

    Guerrero-Preston Rafael; Lawson Fahcina; Rodriguez-Torres Sebastian; Noordhuis Maartje G.; Pirini Francesca; Manuel Laura; Valle Blanca L.; Hadar Tal; Rivera Bianca; Folawiyo Oluwasina; Baez Adriana; Marchionni Luigi; Koch Wayne M.; Westra William H.; Kim Young J.; Eshleman James R.; Sidransky David;

  • 作者单位

    Johns Hopkins Univ Sch Med Dept Otolaryngol &

    Head &

    Neck Surg Baltimore MD USA;

    Johns Hopkins Univ Sch Med Dept Otolaryngol &

    Head &

    Neck Surg Baltimore MD USA;

    Johns Hopkins Univ Sch Med Dept Otolaryngol &

    Head &

    Neck Surg Baltimore MD USA;

    Johns Hopkins Univ Sch Med Dept Otolaryngol &

    Head &

    Neck Surg Baltimore MD USA;

    IRCCS Biosci Lab Ist Sci Romagnolo Studio &

    Cura Tumori IRST Meldola Italy;

    Univ Texas Hlth Sci Ctr San Antonio Dept Epidemiol &

    Biostat San Antonio TX 78229 USA;

    Johns Hopkins Univ Sch Med Dept Otolaryngol &

    Head &

    Neck Surg Baltimore MD USA;

    Shaare Zedek Med Ctr Dept Gen Surg Breast Hlth Unit Jerusalem Israel;

    Univ Puerto Rico Sch Med Dept Otolaryngol San Juan PR 00936 USA;

    Johns Hopkins Univ Sch Med Dept Otolaryngol &

    Head &

    Neck Surg Baltimore MD USA;

    Univ Puerto Rico Sch Med Dept Otolaryngol San Juan PR 00936 USA;

    Johns Hopkins Univ Sch Med Dept Oncol Baltimore MD 21205 USA;

    Johns Hopkins Univ Sch Med Dept Otolaryngol &

    Head &

    Neck Surg Baltimore MD USA;

    Mt Sinai Hosp Dept Pathol Icahn Sch Med New York NY 10029 USA;

    Vanderbilt Univ Sch Med Dept Otolaryngol Nashville TN 37212 USA;

    Johns Hopkins Univ Sch Med Dept Pathol Baltimore MD 21205 USA;

    Johns Hopkins Univ Sch Med Dept Otolaryngol &

    Head &

    Neck Surg Baltimore MD USA;

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  • 正文语种 eng
  • 中图分类 肿瘤学;
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