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Matrix Gla Protein, Plaque Stability, and Cardiovascular Events in Patients with Severe Atherosclerotic Disease

机译：严重动脉粥样硬化疾病患者的基质GLA蛋白，斑块稳定性和心血管事件

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Objective: This study aims to investigate whether plasma matrix Gla protein (MGP) species, desphospho-uncarboxylated (dp-uc) MGP, and total uncarboxylated (t-uc) MGP are associated with plaque levels of uncarboxylated (uc) MGP, markers of plaque stability, and cardiovascular disease (CVD) risk. Methods: From the Athero-Express biobank, we selected carotid plaque samples of 100 patients who underwent carotid endarterectomy. The level of agreement between plasma MGP species and plaque ucMGP levels was assessed using weighted kappa (). We analyzed histological characteristics of plaque composition (plaque hemorrhage, lipid and calcification content). Logistic regression analyses were used to assess the association between plasma MGP and plaque characteristics. Furthermore, CVD endpoints (n = 20) were collected over a mean follow-up of 2.6 years. Results: Weighted statistics of plasma dp-ucMGP and t-ucMGP and plaque ucMGP were 0.10 (95% CI -0.31 to 0.52) and 0.14 (95% CI -0.20 to 0.48). Higher dp-ucMGP levels tended to be associated with less plaque hemorrhage (ORper 500 nM 0.96; 95% CI 0.92-1.00). No association was found for lipid and calcification content. Cox proportional hazards models showed no association between dp-ucMGP (HRper 200 pM 0.92; 95% CI 0.75-1.11) and an inverse association between t-ucMGP (HRper 500 nM 0.79; 95% CI 0.62-0.99) and cardiovascular events. Conclusions: Plasma dp-ucMGP and t-ucMGP concentrations do not reflect plaque ucMGP levels. Elevated dp-ucMGP levels may be associated with less plaque hemorrhage, suggestive of more stable plaques. T-ucMGP was not related with markers of plaque stability; however, elevated plasma t-ucMGP levels were associated with a reduced CVD risk.
机译：目的：本研究旨在研究血浆基质GLA蛋白（MGP）物种，脱磷酰基 - 无羧化（DP-UC）MGP和总无甲基化（T-UC）MGP与斑块水平的无羧化（UC）MGP，标志物相关斑块稳定性，心血管疾病（CVD）风险。方法：从Athero-Express Biobank，我们选择了100名患有颈动脉管切除术的患者的颈动脉斑块样品。使用加权Kappa（）评估血浆MGP物种和斑块UCMGP水平之间的一致性水平。我们分析了斑块组合物的组织学特征（斑块出血，脂质和钙化含量）。逻辑回归分析用于评估血浆MGP和斑块特性之间的关联。此外，CVD端点（n = 20）被收集在平均随访2.6岁。结果：血浆DP-UCMGP和T-UCMGP和斑块UCMGP的加权统计为0.10（95％CI-0.31至0.52）和0.14（95％CI -0.20至0.48）。较高的DP-UCMGP水平往往与较少的斑块出血（ORPER 500nm 0.96; 95％CI 0.92-1.00）相关联。没有发现脂质和钙化含量的关联。 COX比例危害模型在DP-UCMGP（HRPE 200 PM 0.92; 95％CI 0.75-1.11）之间没有关联，T-UCMGP（HRPER 500nm 0.79; 95％CI 0.62-0.99）和心血管事件之间的反相关联。结论：血浆DP-UCMGP和T-UCMGP浓度不反映斑块UCMGP水平。升高的DP-UCMGP水平可能与较少的斑块出血相关，暗示更稳定的斑块。 T-UCMGP与斑块稳定性标记无关;然而，升高的血浆T-UCMGP水平与降低的CVD风险相关。

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