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Beneficial Effects of Vaccination on Cardiovascular Events: Myocardial Infarction, Stroke, Heart Failure

机译:疫苗接种对心血管事件的有益效果:心肌梗死,中风,心力衰竭

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Influenza and pneumococcal infections have been suggested to be potential risk factors for causing adverse cardiovascular events, especially in high-risk patients. Vaccination against respiratory infections in patients with established cardiovascular disease (CVD) could serve as a potential cost-effective intervention to improve their clinical outcomes and cardiac societies have encouraged it. Previous studies have shown that influenza vaccination reduce mortality, acute coronary syndromes and hospitalization in patients with coronary heart disease (CHD) and/or heart failure (HF). However, there is a paucity of randomized prospective clinical trials in the field of the pneumococcal vaccination, and additional higher-quality evidence is needed. Furthermore, questions around the role of vaccination in the primary prevention of CVD, the optimal dose and timing are largely unanswered. The pathophysiologic mechanism in which vaccination provides cardiovascular protection may be related to the modification of the immune-inflammatory model of atherogenesis. The present review summarizes the current evidence and understanding for vaccination against influenza and streptococcus pneumoniae in CHD, HF and stroke and highlights its beneficial effect in the reduction of adverse cardiovascular events. (C) 2018 S. Karger AG, Basel
机译:已经提出了流感和肺炎球菌感染是导致不良心血管事件的潜在危险因素,特别是在高危患者中。患有成熟心血管疾病(CVD)患者的呼吸道感染疫苗接种可以作为改善其临床结果和心脏社会的潜在的性价比干预。以前的研究表明,流感疫苗接种减少死亡率,冠心病(CHD)和/或心力衰竭(HF)患者中的死亡率,急性冠状动脉综合征和住院治疗。然而,在肺炎球菌疫苗接种领域存在缺乏随机性前瞻性临床试验,并且需要额外的更高质量证据。此外,围绕疫苗接种在初步防止CVD中的作用,最佳剂量和时序的问题在很大程度上是未答复的。其中疫苗接种提供心血管保护的病理生理机制可能与血管发生的免疫炎症模型的修饰有关。本综述总结了目前在CHD,HF和中风中针对流感和链球菌肺炎的疫苗接种的证据和理解,并强调其在减少不良心血管事件中的有益效果。 (c)2018年S. Karger AG,巴塞尔

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